Scientific Core Facilities are specialized service centers within research institutions that provide access to advanced technologies, equipment, and expertise. These centers are coupled with experts who provide training, technical support, education, and consultation to help researchers and students use the equipment effectively. We will use the story of our facility to show how unique it was to offer services focused purely on bioAFM and other specialized microscopies (e.g., Raman) in an area where electron microscopy or mass spectrometry laboratories routinely operate. Only through intensive contact with colleagues, involvement in education, and convincing them to plan experiments could we use methods such as force microscopy in different modes to help deliver useful results in various bio-related projects. Examples include imaging single molecules, determining the effect of mechanical properties of the environment or the effect of nanoparticles on the growth and other properties of cells, and monitoring pathological phenomena in organs, such as the formation and treatment of fibrosis in liver tissue samples.