LADUNGOVÁ, Adriana, Daniel BUŠA, Yusuf LODHI, Jan HÝL, Martin ČULEN and Michal ŠMÍDA. Identificationof novel therapeutic options for venetoclax-resistant AML cells through drug repurposing. In 23. Pražské hematologické dny, Praha. 2023.
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Original name Identificationof novel therapeutic options for venetoclax-resistant AML cells through drug repurposing.
Authors LADUNGOVÁ, Adriana, Daniel BUŠA, Yusuf LODHI, Jan HÝL, Martin ČULEN and Michal ŠMÍDA.
Edition 23. Pražské hematologické dny, Praha, 2023.
Other information
Original language English
Type of outcome Konferenční abstrakta
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Středoevropský technologický institut – Repository – Repository
Keywords in English Acute myeloid leukemia; venetoclax-resistance; high-throughput screenings;
Links LX22NPO5102, research and development project. MUNI/A/1330/2021, interní kód Repo. MUNI/A/1419/2021, interní kód Repo.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 23/3/2024 03:48.
Abstract
Acute myeloid leukemia (AML) is a malignant disease derived from the bone marrow precursors of myeloid lineage Treatment options are rather limited, primarily based on chemotherapy, and often result in disease progression Recently, venetoclax-based therapies have transformed the frontline regimens of elderly patients and patients unfit for intensive chemotherapy. Despite its promising outcomes in clinical studies, multiple resistant subclones evolved during the treatment acting as a barrier in disease regression Understanding the venetoclax-resistance mechanisms and detecting the major determinants could reveal previously unrecognized novel perspectives for therapeutic strategies to improve patients’ outcomes. Moreover, performing high-throughput screenings with clinically approved drugs could reveal novel treatment options for resistant subclones of AML.
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  • a concrete person Mgr. Michal Maňas, uco 2481
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