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@article{56651,
   author = {Govarts, Eva and Gilles, Liese and Martin, Laura Rodriguez and Santonen, Tiina and Apel, Petra and Alvito, Paula and Anastasi, Elena and Andersen, Helle Raun and Andersson, AnnaandMaria and Andrýsková, Lenka and Antignacj, JeanandPhilippe and Appenzeller, Brice and Barbone, Fabio and BarnettandItzhaki, Zohar and Barouki, Robert and Berman, Tamar and Bil, Wieneke and Borges, Teresa and Buekers, Jurgen and CanasandPortilla, Ana and Covaci, Adrian and Csako, Zsofia and Elly, Den Hond and Dvorakova, Darina and Fabelova, Lucia and Fletcherx, Tony and Frederiksen, Hanne and Gabriel, Catherine and Ganzleben, Catherine and Goen, Thomas and Halldorsson, Thorhallur I. and Haug, Line S. and Horvat, Milena and Huuskonen, Pasi and Imboden, Medea and Hudobivnik, Marta Jagodic and Janasik, Beata and Holcer, Natasa Janev and Karakitsios, Spyros and Katsonouri, Andromachi and Klánová, Jana and Kokaraki, Venetia and Jensen, Tina Kold and Koponen, Jani and Laeremans, Michelle and Laguzzi, Federica and Lange, Rosa and Lemke, Nora and Lignell, Sanna and Lindroos, Anna Karin and Vicente, Joana Lobo and Luijten, Mirjam and Makris, Konstantinos C. and Mazej, Darja and Melymuk, Lisa Emily and Meslin, Matthieu and Molar, Hans and Montazeri, Parisa and Murawski, Aline and Namorado, Sonia and Niemann, Lars and Nabler, Stefanie and Nunes, Baltazar and Olafsdottir, Kristin and Murinova, Lubica Palkovicova and Papaioannou, Nafsika and PedrazaandDiaz, Susana and Piler, Pavel and Plichta, Veronika and Poteser, Michael and ProbstandHensch, Nicole and Rambaud, Loic and RauscherandGabernig, Elke and Rausova, Katarina and Remy, Sylvie and Riou, Margaux and Rosolen, Valentina and Rousselle, Christophe and Rather, Maria and Sarigiannis, Denis and Silva, Maria J. and Slejkovec, Zdenka and Tratnik, Janja Snoj and Stajnko, Anja and Szigeti, Tamas and Jose, V. Tarazona and Thomsen, Cathrine and Tkalec, Ziga and Tolonen, Hanna and Trnovec, Tomas and Uhl, Maria and An, Van Nieuwenhuyse and Vasco, Elsa and Verheyen, Veerle J. and Viegas, Susana and Vinggaard, Anne Marie and Vogel, Nina and Vorkamp, Katrin and Wasowicz, Wojciech and Weber, Till and Wimmerova, Sona and Woutersen, Marjolijn and Zimmermann, Philipp and Zvonař, Martin and Koch, Holger and KolossaandGehring, Marike and Lopez, Marta Esteban and Castano, Argelia and Stewartx, Lorraine and Sepaix, Ovnair and Schoeters, Greet},
   article_location = {GERMANY},
   article_number = {April 2023},
   doi = {http://dx.doi.org/10.1016/j.ijheh.2023.114119},
   keywords = {Human biomonitoring (HBM); Children; Teenagers; Adults; Exposure biomarkers; HBM4EU},
   language = {eng},
   issn = {1438-4639},
   journal = {INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH},
   title = {Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)},
   url = {https://www.sciencedirect.com/science/article/pii/S143846392300010X?via%3Dihub},
   volume = {249},
   year = {2023}
}

TY  - JOUR
ID  - 56651
AU  - Govarts, Eva - Gilles, Liese - Martin, Laura Rodriguez - Santonen, Tiina - Apel, Petra - Alvito, Paula - Anastasi, Elena - Andersen, Helle Raun - Andersson, Anna-Maria - Andrýsková, Lenka - Antignacj, Jean-Philippe - Appenzeller, Brice - Barbone, Fabio - Barnett-Itzhaki, Zohar - Barouki, Robert - Berman, Tamar - Bil, Wieneke - Borges, Teresa - Buekers, Jurgen - Canas-Portilla, Ana - Covaci, Adrian - Csako, Zsofia - Elly, Den Hond - Dvorakova, Darina - Fabelova, Lucia - Fletcherx, Tony - Frederiksen, Hanne - Gabriel, Catherine - Ganzleben, Catherine - Goen, Thomas - Halldorsson, Thorhallur I. - Haug, Line S. - Horvat, Milena - Huuskonen, Pasi - Imboden, Medea - Hudobivnik, Marta Jagodic - Janasik, Beata - Holcer, Natasa Janev - Karakitsios, Spyros - Katsonouri, Andromachi - Klánová, Jana - Kokaraki, Venetia - Jensen, Tina Kold - Koponen, Jani - Laeremans, Michelle - Laguzzi, Federica - Lange, Rosa - Lemke, Nora - Lignell, Sanna - Lindroos, Anna Karin - Vicente, Joana Lobo - Luijten, Mirjam - Makris, Konstantinos C. - Mazej, Darja - Melymuk, Lisa Emily - Meslin, Matthieu - Molar, Hans - Montazeri, Parisa - Murawski, Aline - Namorado, Sonia - Niemann, Lars - Nabler, Stefanie - Nunes, Baltazar - Olafsdottir, Kristin - Murinova, Lubica Palkovicova - Papaioannou, Nafsika - Pedraza-Diaz, Susana - Piler, Pavel - Plichta, Veronika - Poteser, Michael - Probst-Hensch, Nicole - Rambaud, Loic - Rauscher-Gabernig, Elke - Rausova, Katarina - Remy, Sylvie - Riou, Margaux - Rosolen, Valentina - Rousselle, Christophe - Rather, Maria - Sarigiannis, Denis - Silva, Maria J. - Slejkovec, Zdenka - Tratnik, Janja Snoj - Stajnko, Anja - Szigeti, Tamas - Jose, V. Tarazona - Thomsen, Cathrine - Tkalec, Ziga - Tolonen, Hanna - Trnovec, Tomas - Uhl, Maria - An, Van Nieuwenhuyse - Vasco, Elsa - Verheyen, Veerle J. - Viegas, Susana - Vinggaard, Anne Marie - Vogel, Nina - Vorkamp, Katrin - Wasowicz, Wojciech - Weber, Till - Wimmerova, Sona - Woutersen, Marjolijn - Zimmermann, Philipp - Zvonař, Martin - Koch, Holger - Kolossa-Gehring, Marike - Lopez, Marta Esteban - Castano, Argelia - Stewartx, Lorraine - Sepaix, Ovnair - Schoeters, Greet
PY  - 2023
TI  - Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
JF  - INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
VL  - 249
IS  - April 2023
SP  - 1-21
EP  - 1-21
PB  - ELSEVIER GMBH
SN  - 1438-4639
KW  - Human biomonitoring (HBM)
KW  - Children
KW  - Teenagers
KW  - Adults
KW  - Exposure biomarkers
KW  - HBM4EU
UR  - https://www.sciencedirect.com/science/article/pii/S143846392300010X?via%3Dihub
N2  - As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per-and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzo-phenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from house-holds with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Sigma (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.
ER  - 

GOVARTS, Eva, Liese GILLES, Laura Rodriguez MARTIN, Tiina SANTONEN, Petra APEL, Paula ALVITO, Elena ANASTASI, Helle Raun ANDERSEN, Anna-Maria ANDERSSON, Lenka ANDRÝSKOVÁ, Jean-Philippe ANTIGNACJ, Brice APPENZELLER, Fabio BARBONE, Zohar BARNETT-ITZHAKI, Robert BAROUKI, Tamar BERMAN, Wieneke BIL, Teresa BORGES, Jurgen BUEKERS, Ana CANAS-PORTILLA, Adrian COVACI, Zsofia CSAKO, Den Hond ELLY, Darina DVORAKOVA, Lucia FABELOVA, Tony FLETCHERX, Hanne FREDERIKSEN, Catherine GABRIEL, Catherine GANZLEBEN, Thomas GOEN, Thorhallur I. HALLDORSSON, Line S. HAUG, Milena HORVAT, Pasi HUUSKONEN, Medea IMBODEN, Marta Jagodic HUDOBIVNIK, Beata JANASIK, Natasa Janev HOLCER, Spyros KARAKITSIOS, Andromachi KATSONOURI, Jana KLÁNOVÁ, Venetia KOKARAKI, Tina Kold JENSEN, Jani KOPONEN, Michelle LAEREMANS, Federica LAGUZZI, Rosa LANGE, Nora LEMKE, Sanna LIGNELL, Anna Karin LINDROOS, Joana Lobo VICENTE, Mirjam LUIJTEN, Konstantinos C. MAKRIS, Darja MAZEJ, Lisa Emily MELYMUK, Matthieu MESLIN, Hans MOLAR, Parisa MONTAZERI, Aline MURAWSKI, Sonia NAMORADO, Lars NIEMANN, Stefanie NABLER, Baltazar NUNES, Kristin OLAFSDOTTIR, Lubica Palkovicova MURINOVA, Nafsika PAPAIOANNOU, Susana PEDRAZA-DIAZ, Pavel PILER, Veronika PLICHTA, Michael POTESER, Nicole PROBST-HENSCH, Loic RAMBAUD, Elke RAUSCHER-GABERNIG, Katarina RAUSOVA, Sylvie REMY, Margaux RIOU, Valentina ROSOLEN, Christophe ROUSSELLE, Maria RATHER, Denis SARIGIANNIS, Maria J. SILVA, Zdenka SLEJKOVEC, Janja Snoj TRATNIK, Anja STAJNKO, Tamas SZIGETI, V. Tarazona JOSE, Cathrine THOMSEN, Ziga TKALEC, Hanna TOLONEN, Tomas TRNOVEC, Maria UHL, Van Nieuwenhuyse AN, Elsa VASCO, Veerle J. VERHEYEN, Susana VIEGAS, Anne Marie VINGGAARD, Nina VOGEL, Katrin VORKAMP, Wojciech WASOWICZ, Till WEBER, Sona WIMMEROVA, Marjolijn WOUTERSEN, Philipp ZIMMERMANN, Martin ZVONAŘ, Holger KOCH, Marike KOLOSSA-GEHRING, Marta Esteban LOPEZ, Argelia CASTANO, Lorraine STEWARTX, Ovnair SEPAIX and Greet SCHOETERS. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021). \textit{INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH}. GERMANY: ELSEVIER GMBH, 2023, vol.~249, April 2023, p.~1-21. ISSN~1438-4639. Available from: https://dx.doi.org/10.1016/j.ijheh.2023.114119.