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@article{35946,
author = {Giallongo, Sebastiano and Lo Re, Oriana and Vinciguerra, Manlio},
article_location = {BASEL},
article_number = {5},
keywords = {gastrointestinal cancer; histone variants; epigenetics; macroH2A},
language = {eng},
issn = {2072-6694},
journal = {Cancers},
title = {Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers},
url = {https://www.mdpi.com/2072-6694/11/5/676/htm},
volume = {11},
year = {2019}
}
TY - JOUR
ID - 35946
AU - Giallongo, Sebastiano - Lo Re, Oriana - Vinciguerra, Manlio
PY - 2019
TI - Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers
JF - Cancers
VL - 11
IS - 5
SP - 1-16
EP - 1-16
PB - MDPI
SN - 2072-6694
KW - gastrointestinal cancer
KW - histone variants
KW - epigenetics
KW - macroH2A
UR - https://www.mdpi.com/2072-6694/11/5/676/htm
N2 - Gastrointestinal cancers (GC) are malignancies involving the gastrointestinal (GI) tract and accessory organs of the digestive system, including the pancreas, liver, and gall bladder. GC is one of the most common cancers and contributes to more cancer-related deaths than cancers of any other system in the human body. Causative factors of GC have been consistently attributed to infections, smoking, an unhealthy diet, obesity, diabetes, and genetic factors. More recently, aberrant epigenetic regulation of gene expression has emerged as a new, fundamental pathway in GC pathogenesis. In this review, we summarize the role of the macroH2A histone family in GI cell function and malignant transformation, and highlight how this histone family may open up novel biomarkers for cancer detection, prediction, and response to treatment
ER -
GIALLONGO, Sebastiano, Oriana LO RE a Manlio VINCIGUERRA. Macro Histone Variants: Emerging Rheostats of Gastrointestinal Cancers. \textit{Cancers}. BASEL: MDPI, roč.~11, č.~5, s.~1-16. ISSN~2072-6694. 2019.
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