| HEGER, Zbynek, Hana POLANSKÁ, Miguel Angel Merlos RODRIGO, Roman GURÁŇ, Pavel KULICH, Pavel KOPEL, Michal MASAŘÍK, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK a Vojtech ADAM. Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. Scientific Reports. London: Nature Publishing Group, roč. 6, č. 33379, s. 1-11. ISSN 2045-2322. 2016. |
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@article{22826,
author = {Heger, Zbynek and Polanská, Hana and Rodrigo, Miguel Angel Merlos and Guráň, Roman and Kulich, Pavel and Kopel, Pavel and Masařík, Michal and Eckschlager, Tomas and Stiborova, Marie and Kizek, Rene and Adam, Vojtech},
article_location = {London},
article_number = {33379},
keywords = {CANCER PROGRESSION; CELL-LINE; IN-VITRO; METALLOTHIONEIN; EXPRESSION; THERAPY; PROTEIN; URINE; NANOPARTICLES; TRAFFICKING},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes},
url = {http://www.nature.com/articles/srep33379},
volume = {6},
year = {2016}
}
TY - JOUR
ID - 22826
AU - Heger, Zbynek - Polanská, Hana - Rodrigo, Miguel Angel Merlos - Guráň, Roman - Kulich, Pavel - Kopel, Pavel - Masařík, Michal - Eckschlager, Tomas - Stiborova, Marie - Kizek, Rene - Adam, Vojtech
PY - 2016
TI - Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes
JF - Scientific Reports
VL - 6
IS - 33379
SP - 1-11
EP - 1-11
PB - Nature Publishing Group
SN - 2045-2322
KW - CANCER PROGRESSION
KW - CELL-LINE
KW - IN-VITRO
KW - METALLOTHIONEIN
KW - EXPRESSION
KW - THERAPY
KW - PROTEIN
KW - URINE
KW - NANOPARTICLES
KW - TRAFFICKING
UR - http://www.nature.com/articles/srep33379
N2 - Herein, we describe the preparation of liposomes with folate-targeting properties for the encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive inhibitory effects of exogenously added folic acid supported the role of folate targeting in liposome internalization. We examined the effects of repeated administration on mice PC-3 xenografts. Sar@LIP treatment significantly increased tumor volume and weight compared to controls treated with empty liposomes. Moreover, antisarAbs@LIP administration exhibited a mild antitumor effect. We also identified differences in gene expression patterns post-treatment. Furthermore, Sar@LIP treatment resulted in decreased amounts of tumor zinc ions and total metallothioneins. Examination of the spatial distribution across the tumor sections revealed a sarcosine-related decline of the MT1X isoform within the marginal regions but an elevation after antisarAbs@LIP administration. Our exploratory results demonstrate the importance of sarcosine as an oncometabolite in PCa. Moreover, we have shown that sarcosine can be a potential target for anticancer strategies in management of PCa.
ER -
HEGER, Zbynek, Hana POLANSKÁ, Miguel Angel Merlos RODRIGO, Roman GURÁŇ, Pavel KULICH, Pavel KOPEL, Michal MASAŘÍK, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK a Vojtech ADAM. Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. \textit{Scientific Reports}. London: Nature Publishing Group, roč.~6, č.~33379, s.~1-11. ISSN~2045-2322. 2016.
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