HEGER, Zbynek, Hana POLANSKÁ, Miguel Angel Merlos RODRIGO, Roman GURÁŇ, Pavel KULICH, Pavel KOPEL, Michal MASAŘÍK, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK and Vojtech ADAM. Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. Scientific Reports. London: Nature Publishing Group, 2016, vol. 6, No 33379, p. 1-11. ISSN 2045-2322. |
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@article{22826, author = {Heger, Zbynek and Polanská, Hana and Rodrigo, Miguel Angel Merlos and Guráň, Roman and Kulich, Pavel and Kopel, Pavel and Masařík, Michal and Eckschlager, Tomas and Stiborova, Marie and Kizek, Rene and Adam, Vojtech}, article_location = {London}, article_number = {33379}, keywords = {CANCER PROGRESSION; CELL-LINE; IN-VITRO; METALLOTHIONEIN; EXPRESSION; THERAPY; PROTEIN; URINE; NANOPARTICLES; TRAFFICKING}, language = {eng}, issn = {2045-2322}, journal = {Scientific Reports}, title = {Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes}, url = {http://www.nature.com/articles/srep33379}, volume = {6}, year = {2016} }
TY - JOUR ID - 22826 AU - Heger, Zbynek - Polanská, Hana - Rodrigo, Miguel Angel Merlos - Guráň, Roman - Kulich, Pavel - Kopel, Pavel - Masařík, Michal - Eckschlager, Tomas - Stiborova, Marie - Kizek, Rene - Adam, Vojtech PY - 2016 TI - Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes JF - Scientific Reports VL - 6 IS - 33379 SP - 1-11 EP - 1-11 PB - Nature Publishing Group SN - 2045-2322 KW - CANCER PROGRESSION KW - CELL-LINE KW - IN-VITRO KW - METALLOTHIONEIN KW - EXPRESSION KW - THERAPY KW - PROTEIN KW - URINE KW - NANOPARTICLES KW - TRAFFICKING UR - http://www.nature.com/articles/srep33379 N2 - Herein, we describe the preparation of liposomes with folate-targeting properties for the encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive inhibitory effects of exogenously added folic acid supported the role of folate targeting in liposome internalization. We examined the effects of repeated administration on mice PC-3 xenografts. Sar@LIP treatment significantly increased tumor volume and weight compared to controls treated with empty liposomes. Moreover, antisarAbs@LIP administration exhibited a mild antitumor effect. We also identified differences in gene expression patterns post-treatment. Furthermore, Sar@LIP treatment resulted in decreased amounts of tumor zinc ions and total metallothioneins. Examination of the spatial distribution across the tumor sections revealed a sarcosine-related decline of the MT1X isoform within the marginal regions but an elevation after antisarAbs@LIP administration. Our exploratory results demonstrate the importance of sarcosine as an oncometabolite in PCa. Moreover, we have shown that sarcosine can be a potential target for anticancer strategies in management of PCa. ER -
HEGER, Zbynek, Hana POLANSKÁ, Miguel Angel Merlos RODRIGO, Roman GURÁŇ, Pavel KULICH, Pavel KOPEL, Michal MASAŘÍK, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK and Vojtech ADAM. Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. \textit{Scientific Reports}. London: Nature Publishing Group, 2016, vol.~6, No~33379, p.~1-11. ISSN~2045-2322.
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