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gt;1kHz), which interfere to create low frequency envelope modulating the target area. Recent work presented the capability of TIS to focus the subthalamic nucleus (STN) and to suppress STN beta oscillations in Parkinson's disease. Here, we present temporal and spatial characteristics of this modulation technique. Methods: Implanted DBS leads were temporally externalized for local field potentials (LFP) recording in 8 patients with Parkinson's disease indicated for STN- DBS. STN- TIS was performed by 2 pairs (f1 = 9.00kHz; f2 = 9.13kHz, 2mA per pair max.) of scalp electrodes placed in frontoparietal regions for 3 minutes. The following 3 minutes of resting- state were then used for LFP evaluation. Results: Suppressed beta activity in STN re- occurred back in approx. 120 seconds for STN- TIS. In control condition, where conventional DBS was used, the after- effect varied across group and in some patients was more immediate than TIS. No electrical field enhancement around the DBS lead was found in case of transcranial TIS. Conclusion: TIS is a different type of neuromodulation, applied in a sinusoidal pattern at a sub- threshold intensity; DBS is a pulsed pattern supra- threshold intensity stimulation that generates action potentials. Despite these different mechanisms of action there is growing evidence that TIS has the potential to influence deep brain oscillatory activity and induce clinical effects in a way similar to DBS.