k 2025

Sex-Specific Temporal Proteomic Signatures in the Juvenile Rat Hippocampus After Pilocarpine-Induced Status Epilepticus

SHAKERZADEH, Jalleh; Radim JAROUŠEK; Zita GOLIÁŠOVÁ; Milan BRÁZDIL; H. KUBOVA et al.

Basic information

Original name

Sex-Specific Temporal Proteomic Signatures in the Juvenile Rat Hippocampus After Pilocarpine-Induced Status Epilepticus

Authors

SHAKERZADEH, Jalleh; Radim JAROUŠEK; Zita GOLIÁŠOVÁ; Milan BRÁZDIL and H. KUBOVA

Edition

36th International Epilepsy Congress, Lisbon, Portugal, 2025

Other information

Language

English

Type of outcome

Presentations at conferences

Country of publisher

Portugal

Confidentiality degree

is not subject to a state or trade secret

References:

Marked to be transferred to RIV

No

Organization

Lékařská fakulta – Repository – Repository

Keywords in English

hippocampus; temporal proteomic alterations; immature rats

Links

LX22NPO5107, research and development project.
Changed: 29/11/2025 00:50, RNDr. Daniel Jakubík

Abstract

In the original language

• Early-life seizures are a major risk factor for long-term neurodevelopmental problems and chronic epilepsy. • The immature brain responds differently to injury compared to the adult brain, with sex influencing both vulnerability and recovery patterns. • Status epilepticus during development can trigger widespread molecular changes in the hippocampus that shape the course of epileptogenesis. • Studying these changes over time provides insight into the balance between injury and repair, and may reveal why outcomes differ between males and females.