Anti-biofilm and anti-quorum sensing activities of
galloylquinic acid against clinical isolates of
multidrug-resistant Pseudomonas aeruginosa in open wound
infection: in vitro and in vivo efficacy studies

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Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of ...

Přehled o publikaci

J 2025

Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies

AL-MADDBOLY, Lamiaa A., Mohamed Abd EL-SALAM, Jairo K. BASTOS, Eiman A. HASBY, Ivan KUSHKEVYCH et. al.

Basic information

Original name

Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies

Authors

AL-MADDBOLY, Lamiaa A., Mohamed Abd EL-SALAM, Jairo K. BASTOS, Eiman A. HASBY, Ivan KUSHKEVYCH and Rasha M. EL-MORSI

Edition

BMC Microbiology, London, BioMed Central, 2025, 1471-2180

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1186/s12866-024-03712-8

UT WoS

001464224500005

EID Scopus

2-s2.0-105003001842

Keywords in English

Antibacterial; Pseudomonas aeruginosa; Anti-biofilm; Galloylquinic acid compounds

Changed: 6/6/2025 00:50, RNDr. Daniel Jakubík

Abstract

V originále

lt; 0.05) reduced rhamnolipid, pyocyanin, and the swarming motility of the organism which play a vital role in the biofilm formation. GQAs downregulated 89% of the quorum-sensing genes (lasI and lasR, pqsA and pqsR) involved in the biofilm formation. Conclusion: GQAs demonstrate significant promise as novel and potent antibiofilm and antivirulence agents against clinical isolates of MDR P. aeruginosa, with substantial potential to enhance wound healing in biofilm-associated infections. This promising antibacterial action positions GQAs as a superior alternative for the treatment of biofilm-associated wound infections, with substantial potential to improve wound healing and mitigate the impact of persistent bacterial infections. Clinical trial number: not applicable.

Files attached

https://is.muni.cz/publication/2490112/2490112.pdf

Cite

AL-MADDBOLY, Lamiaa A., Mohamed Abd EL-SALAM, Jairo K. BASTOS, Eiman A. HASBY, Ivan KUSHKEVYCH and Rasha M. EL-MORSI. Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies. BMC Microbiology. London: BioMed Central, 2025, vol. 25, No 1, p. 206-223. ISSN 1471-2180. Available from: https://dx.doi.org/10.1186/s12866-024-03712-8.

@article{74947,
   author = {AlandMaddboly, Lamiaa A. and ElandSalam, Mohamed Abd and Bastos, Jairo K. and Hasby, Eiman A. and Kushkevych, Ivan and ElandMorsi, Rasha M.},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12866-024-03712-8},
   keywords = {Antibacterial; Pseudomonas aeruginosa; Anti-biofilm; Galloylquinic acid compounds},
   language = {eng},
   issn = {1471-2180},
   journal = {BMC Microbiology},
   title = {Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies},
   url = {https://doi.org/10.1186/s12866-024-03712-8},
   volume = {25},
   year = {2025}
}

TY  - JOUR
ID  - 74947
AU  - Al-Maddboly, Lamiaa A. - El-Salam, Mohamed Abd - Bastos, Jairo K. - Hasby, Eiman A. - Kushkevych, Ivan - El-Morsi, Rasha M.
PY  - 2025
TI  - Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies
JF  - BMC Microbiology
VL  - 25
IS  - 1
SP  - 206
EP  - 206
PB  - BioMed Central
SN  - 1471-2180
KW  - Antibacterial
KW  - Pseudomonas aeruginosa
KW  - Anti-biofilm
KW  - Galloylquinic acid compounds
UR  - https://doi.org/10.1186/s12866-024-03712-8
N2  - lt; 0.05) reduced rhamnolipid, pyocyanin, and the swarming motility of the organism which play a vital role in the biofilm formation. GQAs downregulated 89% of the quorum-sensing genes (lasI and lasR, pqsA and pqsR) involved in the biofilm formation. Conclusion: GQAs demonstrate significant promise as novel and potent antibiofilm and antivirulence agents against clinical isolates of MDR P. aeruginosa, with substantial potential to enhance wound healing in biofilm-associated infections. This promising antibacterial action positions GQAs as a superior alternative for the treatment of biofilm-associated wound infections, with substantial potential to improve wound healing and mitigate the impact of persistent bacterial infections. Clinical trial number: not applicable.
ER  -

AL-MADDBOLY, Lamiaa A., Mohamed Abd EL-SALAM, Jairo K. BASTOS, Eiman A. HASBY, Ivan KUSHKEVYCH and Rasha M. EL-MORSI. Anti-biofilm and anti-quorum sensing activities of galloylquinic acid against clinical isolates of multidrug-resistant Pseudomonas aeruginosa in open wound infection: in vitro and in vivo efficacy studies. \textit{BMC Microbiology}. London: BioMed Central, 2025, vol.~25, No~1, p.~206-223. ISSN~1471-2180. Available from: https://dx.doi.org/10.1186/s12866-024-03712-8.