Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study
ELSHORBAGY, Amany, Alexander R M LYONS, Antonio J VALLEJO-VAZ, Christophe A T STEVENS, Kanika I DHARMAYAT et. al.
Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study
Authors
ELSHORBAGY, Amany, Alexander R M LYONS, Antonio J VALLEJO-VAZ, Christophe A T STEVENS, Kanika I DHARMAYAT, Julia BRANDTS, Alberico L CATAPANO, Tomáš FREIBERGER, G Kees HOVINGH, Pedro MATA, Frederick J RAAL, Raul D SANTOS, Handrean SORAN, Gerald F WATTS, Marianne ABIFADEL, Carlos A AGUILAR-SALINAS, Khalid F ALHABIB, Mutaz ALKHNIFSAWI, Wael ALMAHMEED, Fahad ALNOURI, Rodrigo ALONSO, Khalid AL-RASADI, Ahmad AL-SARRAF, Tester F ASHAVAID, Maciej BANACH, Christoph J BINDER, Mafalda BOURBON, Liam R BRUNHAM, Krzysztof CHLEBUS, Pablo CORRAL, Diogo CRUZ, Kairat DAVLETOV, Olivier S DESCAMPS, Marat EZHOV, Dan GAITA, Urh GROSELJ, Mariko HARADA-SHIBA, Kirsten B HOLVEN, Meral KAYIKCIOGLU, Weerapan KHOVIDHUNKIT, Katarina LALIC, Gustavs LATKOVSKIS, Ulrich LAUFS, Evangelos LIBEROPOULOS, Marcos M LIMA-MARTINEZ, Jie LIN, Vincent MAHER, A David MARAIS, Winfried MARZ, Erkin MIRRAKHIMOV, Andre R MISEREZ, Olena MITCHENKO, Hapizah NAWAWI, Borge G NORDESTGAARD, Andrie G PANAYIOTOU, Gyorgy PARAGH, Zaneta PETRULIONIENE, Belma POJSKIC, Arman POSTADZHIYAN, Ashraf REDA, Zeljko REINER, Ximena REYES, Fouzia SADIQ, Wilson E SADOH, Heribert SCHUNKERT, Aleksandr B SHEK, Erik STROES, Ta-Chen SU, Tavintharan SUBRAMANIAM, Andrey V SUSEKOV, Myra TILNEY, Brian TOMLINSON, Truong THANH-HUONG, Alexandros D TSELEPIS, Anne TYBJAERG-HANSEN, Alejandra C VAZQUEZ, Margus VIIGIMAA, Branislav VOHNOUT, Luya WANG, Shizuya YAMASHITA, Marcello ARCA, Maurizio AVERNA and Kausik K RAY
Edition
ENDOCRINOLOGY, NEW YORK, ELSEVIER SCIENCE INC, 2024, 2213-8587
Background Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, raising the question of whether these patients are protected against type 2 diabetes. Obesity is a well known risk factor for the development of type 2 diabetes. We aimed to investigate the associations of known key determinants of type 2 diabetes with its prevalence in people with heterozygous familial hypercholesterolaemia.
ELSHORBAGY, Amany, Alexander R M LYONS, Antonio J VALLEJO-VAZ, Christophe A T STEVENS, Kanika I DHARMAYAT, Julia BRANDTS, Alberico L CATAPANO, Tomáš FREIBERGER, G Kees HOVINGH, Pedro MATA, Frederick J RAAL, Raul D SANTOS, Handrean SORAN, Gerald F WATTS, Marianne ABIFADEL, Carlos A AGUILAR-SALINAS, Khalid F ALHABIB, Mutaz ALKHNIFSAWI, Wael ALMAHMEED, Fahad ALNOURI, Rodrigo ALONSO, Khalid AL-RASADI, Ahmad AL-SARRAF, Tester F ASHAVAID, Maciej BANACH, Christoph J BINDER, Mafalda BOURBON, Liam R BRUNHAM, Krzysztof CHLEBUS, Pablo CORRAL, Diogo CRUZ, Kairat DAVLETOV, Olivier S DESCAMPS, Marat EZHOV, Dan GAITA, Urh GROSELJ, Mariko HARADA-SHIBA, Kirsten B HOLVEN, Meral KAYIKCIOGLU, Weerapan KHOVIDHUNKIT, Katarina LALIC, Gustavs LATKOVSKIS, Ulrich LAUFS, Evangelos LIBEROPOULOS, Marcos M LIMA-MARTINEZ, Jie LIN, Vincent MAHER, A David MARAIS, Winfried MARZ, Erkin MIRRAKHIMOV, Andre R MISEREZ, Olena MITCHENKO, Hapizah NAWAWI, Borge G NORDESTGAARD, Andrie G PANAYIOTOU, Gyorgy PARAGH, Zaneta PETRULIONIENE, Belma POJSKIC, Arman POSTADZHIYAN, Ashraf REDA, Zeljko REINER, Ximena REYES, Fouzia SADIQ, Wilson E SADOH, Heribert SCHUNKERT, Aleksandr B SHEK, Erik STROES, Ta-Chen SU, Tavintharan SUBRAMANIAM, Andrey V SUSEKOV, Myra TILNEY, Brian TOMLINSON, Truong THANH-HUONG, Alexandros D TSELEPIS, Anne TYBJAERG-HANSEN, Alejandra C VAZQUEZ, Margus VIIGIMAA, Branislav VOHNOUT, Luya WANG, Shizuya YAMASHITA, Marcello ARCA, Maurizio AVERNA and Kausik K RAY. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study. ENDOCRINOLOGY. NEW YORK: ELSEVIER SCIENCE INC, 2024, vol. 12, No 11, p. 811-823. ISSN 2213-8587. Available from: https://dx.doi.org/10.1016/S2213-8587(24)00221-3.
@article{66649, author = {Elshorbagy, Amany and Lyons, Alexander R M and VallejoandVaz, Antonio J and Stevens, Christophe A T and Dharmayat, Kanika I and Brandts, Julia and Catapano, Alberico L and Freiberger, Tomáš and Hovingh, G Kees and Mata, Pedro and Raal, Frederick J and Santos, Raul D and Soran, Handrean and Watts, Gerald F and Abifadel, Marianne and AguilarandSalinas, Carlos A and Alhabib, Khalid F and Alkhnifsawi, Mutaz and Almahmeed, Wael and Alnouri, Fahad and Alonso, Rodrigo and AlandRasadi, Khalid and AlandSarraf, Ahmad and Ashavaid, Tester F and Banach, Maciej and Binder, Christoph J and Bourbon, Mafalda and Brunham, Liam R and Chlebus, Krzysztof and Corral, Pablo and Cruz, Diogo and Davletov, Kairat and Descamps, Olivier S and Ezhov, Marat and Gaita, Dan and Groselj, Urh and HaradaandShiba, Mariko and Holven, Kirsten B and Kayikcioglu, Meral and Khovidhunkit, Weerapan and Lalic, Katarina and Latkovskis, Gustavs and Laufs, Ulrich and Liberopoulos, Evangelos and LimaandMartinez, Marcos M and Lin, Jie and Maher, Vincent and Marais, A David and Marz, Winfried and Mirrakhimov, Erkin and Miserez, Andre R and Mitchenko, Olena and Nawawi, Hapizah and Nordestgaard, Borge G and Panayiotou, Andrie G and Paragh, Gyorgy and Petrulioniene, Zaneta and Pojskic, Belma and Postadzhiyan, Arman and Reda, Ashraf and Reiner, Zeljko and Reyes, Ximena and Sadiq, Fouzia and Sadoh, Wilson E and Schunkert, Heribert and Shek, Aleksandr B and Stroes, Erik and Su, TaandChen and Subramaniam, Tavintharan and Susekov, Andrey V and Tilney, Myra and Tomlinson, Brian and ThanhandHuong, Truong and Tselepis, Alexandros D and TybjaergandHansen, Anne and Vazquez, Alejandra C and Viigimaa, Margus and Vohnout, Branislav and Wang, Luya and Yamashita, Shizuya and Arca, Marcello and Averna, Maurizio and Ray, Kausik K}, article_location = {NEW YORK}, article_number = {11}, doi = {http://dx.doi.org/10.1016/S2213-8587(24)00221-3}, keywords = {BMI; lipid-lowering medication; age; type 2 diabetes; heterozygous familial hypercholesterolaemia}, language = {eng}, issn = {2213-8587}, journal = {ENDOCRINOLOGY}, title = {Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study}, url = {https://www.thelancet.com/journals/landia/article/PIIS2213-8587%2824%2900221-3/fulltext}, volume = {12}, year = {2024} }
TY - JOUR ID - 66649 AU - Elshorbagy, Amany - Lyons, Alexander R M - Vallejo-Vaz, Antonio J - Stevens, Christophe A T - Dharmayat, Kanika I - Brandts, Julia - Catapano, Alberico L - Freiberger, Tomáš - Hovingh, G Kees - Mata, Pedro - Raal, Frederick J - Santos, Raul D - Soran, Handrean - Watts, Gerald F - Abifadel, Marianne - Aguilar-Salinas, Carlos A - Alhabib, Khalid F - Alkhnifsawi, Mutaz - Almahmeed, Wael - Alnouri, Fahad - Alonso, Rodrigo - Al-Rasadi, Khalid - Al-Sarraf, Ahmad - Ashavaid, Tester F - Banach, Maciej - Binder, Christoph J - Bourbon, Mafalda - Brunham, Liam R - Chlebus, Krzysztof - Corral, Pablo - Cruz, Diogo - Davletov, Kairat - Descamps, Olivier S - Ezhov, Marat - Gaita, Dan - Groselj, Urh - Harada-Shiba, Mariko - Holven, Kirsten B - Kayikcioglu, Meral - Khovidhunkit, Weerapan - Lalic, Katarina - Latkovskis, Gustavs - Laufs, Ulrich - Liberopoulos, Evangelos - Lima-Martinez, Marcos M - Lin, Jie - Maher, Vincent - Marais, A David - Marz, Winfried - Mirrakhimov, Erkin - Miserez, Andre R - Mitchenko, Olena - Nawawi, Hapizah - Nordestgaard, Borge G - Panayiotou, Andrie G - Paragh, Gyorgy - Petrulioniene, Zaneta - Pojskic, Belma - Postadzhiyan, Arman - Reda, Ashraf - Reiner, Zeljko - Reyes, Ximena - Sadiq, Fouzia - Sadoh, Wilson E - Schunkert, Heribert - Shek, Aleksandr B - Stroes, Erik - Su, Ta-Chen - Subramaniam, Tavintharan - Susekov, Andrey V - Tilney, Myra - Tomlinson, Brian - Thanh-Huong, Truong - Tselepis, Alexandros D - Tybjaerg-Hansen, Anne - Vazquez, Alejandra C - Viigimaa, Margus - Vohnout, Branislav - Wang, Luya - Yamashita, Shizuya - Arca, Marcello - Averna, Maurizio - Ray, Kausik K PY - 2024 TI - Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study JF - ENDOCRINOLOGY VL - 12 IS - 11 SP - 811-823 EP - 811-823 PB - ELSEVIER SCIENCE INC SN - 2213-8587 KW - BMI KW - lipid-lowering medication KW - age KW - type 2 diabetes KW - heterozygous familial hypercholesterolaemia UR - https://www.thelancet.com/journals/landia/article/PIIS2213-8587%2824%2900221-3/fulltext N2 - Background Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, raising the question of whether these patients are protected against type 2 diabetes. Obesity is a well known risk factor for the development of type 2 diabetes. We aimed to investigate the associations of known key determinants of type 2 diabetes with its prevalence in people with heterozygous familial hypercholesterolaemia. ER -
ELSHORBAGY, Amany, Alexander R M LYONS, Antonio J VALLEJO-VAZ, Christophe A T STEVENS, Kanika I DHARMAYAT, Julia BRANDTS, Alberico L CATAPANO, Tomáš FREIBERGER, G Kees HOVINGH, Pedro MATA, Frederick J RAAL, Raul D SANTOS, Handrean SORAN, Gerald F WATTS, Marianne ABIFADEL, Carlos A AGUILAR-SALINAS, Khalid F ALHABIB, Mutaz ALKHNIFSAWI, Wael ALMAHMEED, Fahad ALNOURI, Rodrigo ALONSO, Khalid AL-RASADI, Ahmad AL-SARRAF, Tester F ASHAVAID, Maciej BANACH, Christoph J BINDER, Mafalda BOURBON, Liam R BRUNHAM, Krzysztof CHLEBUS, Pablo CORRAL, Diogo CRUZ, Kairat DAVLETOV, Olivier S DESCAMPS, Marat EZHOV, Dan GAITA, Urh GROSELJ, Mariko HARADA-SHIBA, Kirsten B HOLVEN, Meral KAYIKCIOGLU, Weerapan KHOVIDHUNKIT, Katarina LALIC, Gustavs LATKOVSKIS, Ulrich LAUFS, Evangelos LIBEROPOULOS, Marcos M LIMA-MARTINEZ, Jie LIN, Vincent MAHER, A David MARAIS, Winfried MARZ, Erkin MIRRAKHIMOV, Andre R MISEREZ, Olena MITCHENKO, Hapizah NAWAWI, Borge G NORDESTGAARD, Andrie G PANAYIOTOU, Gyorgy PARAGH, Zaneta PETRULIONIENE, Belma POJSKIC, Arman POSTADZHIYAN, Ashraf REDA, Zeljko REINER, Ximena REYES, Fouzia SADIQ, Wilson E SADOH, Heribert SCHUNKERT, Aleksandr B SHEK, Erik STROES, Ta-Chen SU, Tavintharan SUBRAMANIAM, Andrey V SUSEKOV, Myra TILNEY, Brian TOMLINSON, Truong THANH-HUONG, Alexandros D TSELEPIS, Anne TYBJAERG-HANSEN, Alejandra C VAZQUEZ, Margus VIIGIMAA, Branislav VOHNOUT, Luya WANG, Shizuya YAMASHITA, Marcello ARCA, Maurizio AVERNA and Kausik K RAY. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study. \textit{ENDOCRINOLOGY}. NEW YORK: ELSEVIER SCIENCE INC, 2024, vol.~12, No~11, p.~811-823. ISSN~2213-8587. Available from: https://dx.doi.org/10.1016/S2213-8587(24)00221-3.
