k 2024

Visualizing the effects of SORLA mutation in Alzheimer’s disease progression

SATKOVÁ, Miriam; Jan RAŠKA; Klára PLEŠINGROVÁ; Soňa CESNÁRIKOVÁ; Jiří SEDMÍK et. al.

Basic information

Original name

Visualizing the effects of SORLA mutation in Alzheimer’s disease progression

Authors

SATKOVÁ, Miriam; Jan RAŠKA; Klára PLEŠINGROVÁ; Soňa CESNÁRIKOVÁ; Jiří SEDMÍK; Hana HŘÍBKOVÁ; Petr FOJTÍK and Dáša BOHAČIAKOVÁ

Edition

2024

Other information

Language

English

Type of outcome

Presentations at conferences

Country of publisher

Czech Republic

Confidentiality degree

is not subject to a state or trade secret

Organization

Lékařská fakulta – Repository – Repository

Keywords in English

SORLA mutation; Alzheimer’s disease progression

Links

LX22NPO5107, research and development project. MUNI/A/1598/2023, interní kód Repo. NU22J-08-00075, research and development project.
Changed: 26/11/2024 00:50, RNDr. Daniel Jakubík

Abstract

V originále

Aim: investigate whether pathogenic mutation Y1816C in SORL1 leads to altered APP processing and enlarged endosomes in human 2D neurons and 3D organoids in vitro.

Files attached

https://is.muni.cz/publication/2454768/Visualizing_the_effects_of_SORLA_mutation_in_Alzheimer_s_disease_progression.pdf File version