J
2024
BenchStab: A tool for automated querying of web-based stability predictors
VELECKÝ, Jan; Matej BEREZNÝ; Miloš MUSIL; Jiří DAMBORSKÝ; David BEDNÁŘ et al.
Basic information
Original name
BenchStab: A tool for automated querying of web-based stability predictors
Authors
VELECKÝ, Jan; Matej BEREZNÝ; Miloš MUSIL; Jiří DAMBORSKÝ; David BEDNÁŘ and Stanislav MAZURENKO
Edition
Bioinformatics, Oxford (UK), Oxford University Press, 2024, 1367-4803
Other information
Type of outcome
Article in a journal
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
is not subject to a state or trade secret
Marked to be transferred to RIV
Yes
RIV identification code
RIV/00216224:14310/24:00137147
Organization
Přírodovědecká fakulta – Repository – Repository
Keywords in English
PROTEIN STABILITY; SERVER; MUTATIONS; CHALLENGES
Links
LM2018140, research and development project. LM2023055, research and development project. LM2023069, research and development project. LX22NPO5107, research and development project. 857560, interní kód Repo.
In the original language
Protein design requires information about how mutations affect protein stability. Many web-based predictors are available for this purpose, yet comparing them or using them en masse is difficult. Here, we present BenchStab, a console tool/Python package for easy and quick execution of 19 predictors and result collection on a list of mutants. Moreover, the tool is easily extensible with additional predictors. We created an independent dataset derived from the FireProtDB and evaluated 24 different prediction methods.Availability and implementation BenchStab is an open-source Python package available at https://github.com/loschmidt/BenchStab with a detailed README and example usage at https://loschmidt.chemi.muni.cz/benchstab. The BenchStab dataset is available on Zenodo: https://zenodo.org/records/10637728
Displayed: 3/5/2026 06:26