Přehled o publikaci
2024
Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study)
PÁLEŠOVÁ, Nina; Katarína ŘIHÁČKOVÁ; Jan KUTA; Aleš PINDUR; Ludmila ŠEBEJOVÁ et al.Basic information
Original name
Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study)
Authors
PÁLEŠOVÁ, Nina; Katarína ŘIHÁČKOVÁ; Jan KUTA; Aleš PINDUR; Ludmila ŠEBEJOVÁ and Pavel ČUPR
Edition
TECHNOLOGY LETTERS, UNITED STATES, AMER CHEMICAL SOC, 2024, 2328-8930
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
Marked to be transferred to RIV
Yes
RIV identification code
RIV/00216224:14310/24:00136259
Organization
Přírodovědecká fakulta – Repository – Repository
UT WoS
EID Scopus
Keywords in English
firefighters; occupational exposure; metals; cholesterol; cardiovascular disease; mixture analysis
Links
101057014, interní kód Repo. 857340, interní kód Repo. 857560, interní kód Repo. 874627, interní kód Repo. BBMRI.cz IV, large research infrastructures. RECETOX RI II, large research infrastructures.
Changed: 24/6/2025 00:50, RNDr. Daniel Jakubík
Abstract
In the original language
Increased wildfire activity increases the demands on fire rescue services and firefighters’ contact with harmful chemicals. This study aimed to determine firefighters’ exposure to toxic metal(loid)s and its association with the lipid profile. CELSPAC-FIREexpo study participants (including 110 firefighters) provided urine and blood samples to quantify urinary levels of metal(loid)s (arsenic, cadmium (Cd), mercury, and lead (Pb)), and serum lipid biomarkers (cholesterol (CHOL), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglycerides (TG)). The associations were investigated by using multiple linear regression and Bayesian weighted quantile sum (BWQS) regression. Higher levels of Pb were observed in firefighters. Pb was positively associated with CHOL and TG. Cd was negatively associated with HDL. In the BWQS model, the mixture of metal(loid)s was associated positively with CHOL (β = 14.75, 95% CrI = 2.45–29.08), LDL (β = 15.14, 95% CrI = 3.39–29.35), and TG (β = 14.79, 95% CrI = 0.73–30.42), while negatively with HDL (β = −14.96, 95% CrI = −25.78 to −1.8). Pb emerged as a key component in a metal(loid) mixture. The results suggest that higher exposure to lead and the mixture of metal(loid)s is associated with the alteration of the lipid profile, which can result in an unfavorable cardiometabolic profile, especially in occupationally exposed firefighters.
