Adjuvant radiotherapy after brain metastasectomy: analysis of
consecutive cohort of 118 patients from real world practice

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Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients ...

Přehled o publikaci

J 2024

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

FADRUS, Pavel; Václav VYBÍHAL; Ivana ROŠKOVÁ; Iveta SELINGEROVÁ; Martin SMRČKA et. al.

Základní údaje

Originální název

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

Autoři

Vydání

Reports of Practical Oncology and Radiotherapy, GDANSK, VIA MEDICA, 2024, 1507-1367

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/24:00136239

Organizace

Lékařská fakulta – Masarykova univerzita – Repozitář

DOI

https://doi.org/10.5603/rpor.99362

UT WoS

001293214500001

EID Scopus

2-s2.0-85188780134

Klíčová slova anglicky

brain metastases; surgery; radiotherapy; tumor cavity; overall survival

Návaznosti

LX22NPO5102, projekt VaV. NU22-03-00159, projekt VaV. NV18-03-00469, projekt VaV. BBMRI.cz IV, velká výzkumná infrastruktura. CZECRIN IV, velká výzkumná infrastruktura.

Změněno: 10. 6. 2025 00:50, RNDr. Daniel Jakubík

Anotace

V originále

lt; 0.001; hazard ratio (HR) 0.47, p = 0.004] with median follow-up of 58 months. Cumulative incidence for local, distant, and extracranial control was not significantly different between groups, with 12-month cumulative control of 22% vs. 18%, 44% vs. 29%, and 35% vs. 32% for stereotactic and WBRT group, respectively. WBRT was an independent factor for better distal brain control. Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidence for local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule with outcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.

Přiložené soubory

https://is.muni.cz/publication/2410538/Adjuvant_radiotherapy_after_brain_metastasectomy_analysis_of_consecutive_cohort_of_118_patients_from_real_world_practice.pdf

Citovat

FADRUS, Pavel; Václav VYBÍHAL; Ivana ROŠKOVÁ; Iveta SELINGEROVÁ; Martin SMRČKA; Radim JANČÁLEK; Jiří ŠÁNA; Ondřej SLABÝ; Petr POSPÍŠIL; Ludmila HYNKOVÁ; Jan GARCIC; Renata BELANOVÁ; Jan KRISTEK; Andrea ŠPRLÁKOVÁ-PUKOVÁ; Zdeněk MACKERLE; Vilém JURÁŇ; Marek SOVA; Eduard NEUMAN; Hana VALEKOVÁ; Radek LAKOMÝ; Miloš HOLÁNEK; Roman HRSTKA; Michaela ŠVAJDOVÁ; Kateřina POLÁCHOVÁ; Ivana KOLOUŠKOVÁ; Pavel ŠLAMPA a Tomáš KAZDA. Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice. Reports of Practical Oncology and Radiotherapy. GDANSK: VIA MEDICA, 2024, roč. 29, č. 1, s. 30-41. ISSN 1507-1367. Dostupné z: https://doi.org/10.5603/rpor.99362.

@article{61606,
   author = {Fadrus, Pavel and Vybíhal, Václav and Rošková, Ivana and Selingerová, Iveta and Smrčka, Martin and Jančálek, Radim and Šána, Jiří and Slabý, Ondřej and Pospíšil, Petr and Hynková, Ludmila and Garcic, Jan and Belanová, Renata and Kristek, Jan and ŠprlákováandPuková, Andrea and Mackerle, Zdeněk and Juráň, Vilém and Sova, Marek and Neuman, Eduard and Valeková, Hana and Lakomý, Radek and Holánek, Miloš and Hrstka, Roman and Švajdová, Michaela and Poláchová, Kateřina and Koloušková, Ivana and Šlampa, Pavel and Kazda, Tomáš},
   article_location = {GDANSK},
   article_number = {1},
   doi = {https://doi.org/10.5603/rpor.99362},
   keywords = {brain metastases; surgery; radiotherapy; tumor cavity; overall survival},
   language = {eng},
   issn = {1507-1367},
   journal = {Reports of Practical Oncology and Radiotherapy},
   title = {Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice},
   url = {https://journals.viamedica.pl/rpor/article/view/99362/77331},
   volume = {29},
   year = {2024}
}

TY  - JOUR
ID  - 61606
AU  - Fadrus, Pavel - Vybíhal, Václav - Rošková, Ivana - Selingerová, Iveta - Smrčka, Martin - Jančálek, Radim - Šána, Jiří - Slabý, Ondřej - Pospíšil, Petr - Hynková, Ludmila - Garcic, Jan - Belanová, Renata - Kristek, Jan - Šprláková-Puková, Andrea - Mackerle, Zdeněk - Juráň, Vilém - Sova, Marek - Neuman, Eduard - Valeková, Hana - Lakomý, Radek - Holánek, Miloš - Hrstka, Roman - Švajdová, Michaela - Poláchová, Kateřina - Koloušková, Ivana - Šlampa, Pavel - Kazda, Tomáš
PY  - 2024
TI  - Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice
JF  - Reports of Practical Oncology and Radiotherapy
VL  - 29
IS  - 1
SP  - 30-41
EP  - 30-41
PB  - VIA MEDICA
SN  - 1507-1367
KW  - brain metastases
KW  - surgery
KW  - radiotherapy
KW  - tumor cavity
KW  - overall survival
UR  - https://journals.viamedica.pl/rpor/article/view/99362/77331
N2  - lt; 0.001; hazard ratio (HR) 0.47, p = 0.004] with median follow-up of 58 months. Cumulative incidence for local, distant, and extracranial control was not significantly different between groups, with 12-month cumulative control of 22% vs. 18%, 44% vs. 29%, and 35% vs. 32% for stereotactic and WBRT group, respectively. WBRT was an independent factor for better distal brain control. Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidence for local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule with outcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.
ER  -

FADRUS, Pavel; Václav VYBÍHAL; Ivana ROŠKOVÁ; Iveta SELINGEROVÁ; Martin SMRČKA; Radim JANČÁLEK; Jiří ŠÁNA; Ondřej SLABÝ; Petr POSPÍŠIL; Ludmila HYNKOVÁ; Jan GARCIC; Renata BELANOVÁ; Jan KRISTEK; Andrea ŠPRLÁKOVÁ-PUKOVÁ; Zdeněk MACKERLE; Vilém JURÁŇ; Marek SOVA; Eduard NEUMAN; Hana VALEKOVÁ; Radek LAKOMÝ; Miloš HOLÁNEK; Roman HRSTKA; Michaela ŠVAJDOVÁ; Kateřina POLÁCHOVÁ; Ivana KOLOUŠKOVÁ; Pavel ŠLAMPA a Tomáš KAZDA. Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice. \textit{Reports of Practical Oncology and Radiotherapy}. GDANSK: VIA MEDICA, 2024, roč.~29, č.~1, s.~30-41. ISSN~1507-1367. Dostupné z: https://doi.org/10.5603/rpor.99362.