Toxicity of external beam accelerated partial-breast
irradiation (APBI) in adjuvant therapy of early-stage breast
cancer: prospective randomized study

ENPřihlásit se Přihlásit se (EduID)

Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of ...

Přehled o publikaci

J 2024

Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study

BURKOŇ, Petr, Iveta SELINGEROVÁ, Marek SLÁVIK, Miloš HOLÁNEK, Miroslav VRZAL et. al.

Základní údaje

Originální název

Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study

Autoři

BURKOŇ, Petr, Iveta SELINGEROVÁ, Marek SLÁVIK, Miloš HOLÁNEK, Miroslav VRZAL, Oldřich COUFAL, Kateřina POLÁCHOVÁ, Petr MULLER, Pavel ŠLAMPA a Tomáš KAZDA

Vydání

Radiation Oncology, BMC, Elsevier, 2024, 1748-717X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizace

Lékařská fakulta – Masarykova univerzita – Repozitář

DOI

http://dx.doi.org/10.1186/s13014-024-02412-x

UT WoS

001155905200001

EID Scopus

2-s2.0-85184096089

Klíčová slova anglicky

Early breast cancer; Adjuvant radiotherapy; Surgical bed; APBI; External beam radiotherapy

Návaznosti

LX22NPO5102, projekt VaV. BBMRI.cz IV, velká výzkumná infrastruktura. CZECRIN IV, velká výzkumná infrastruktura.

Změněno: 15. 3. 2025 00:51, RNDr. Daniel Jakubík

Anotace

V originále

gt;= 2 late skin toxicity was observed (p = 0.026). Late toxicity in the breast area (deformation, edema, fibrosis, and pain), affecting the quality of life and cosmetic effect, occurred in 61% and 17% of patients in WBI and APBI arms, respectively. The cosmetic effect was more favorable in the APBI arm, especially 6 to 12 months after the radiotherapy.ConclusionExternal APBI demonstrated better feasibility and less toxicity than the standard regimen in the adjuvant setting for treating early breast cancer patients. The presented study confirmed the level of evidence for establishing the external APBI in daily clinical practice.Trial registrationNCT06007118.

Přiložené soubory

https://is.muni.cz/publication/2409840/Toxicity_of_external_beam_accelerated_partial-breast_irradiation__APBI__in_adjuvant_therapy_of_early-stage_breast_cancer_prospective_randomized_study.pdf

Citovat

BURKOŇ, Petr, Iveta SELINGEROVÁ, Marek SLÁVIK, Miloš HOLÁNEK, Miroslav VRZAL, Oldřich COUFAL, Kateřina POLÁCHOVÁ, Petr MULLER, Pavel ŠLAMPA a Tomáš KAZDA. Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study. Radiation Oncology. BMC: Elsevier, 2024, roč. 19, č. 1, s. 1-12. ISSN 1748-717X. Dostupné z: https://dx.doi.org/10.1186/s13014-024-02412-x.

@article{61577,
   author = {Burkoň, Petr and Selingerová, Iveta and Slávik, Marek and Holánek, Miloš and Vrzal, Miroslav and Coufal, Oldřich and Poláchová, Kateřina and Muller, Petr and Šlampa, Pavel and Kazda, Tomáš},
   article_location = {BMC},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s13014-024-02412-x},
   keywords = {Early breast cancer; Adjuvant radiotherapy; Surgical bed; APBI; External beam radiotherapy},
   language = {eng},
   issn = {1748-717X},
   journal = {Radiation Oncology},
   title = {Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study},
   url = {https://ro-journal.biomedcentral.com/articles/10.1186/s13014-024-02412-x},
   volume = {19},
   year = {2024}
}

TY  - JOUR
ID  - 61577
AU  - Burkoň, Petr - Selingerová, Iveta - Slávik, Marek - Holánek, Miloš - Vrzal, Miroslav - Coufal, Oldřich - Poláchová, Kateřina - Muller, Petr - Šlampa, Pavel - Kazda, Tomáš
PY  - 2024
TI  - Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study
JF  - Radiation Oncology
VL  - 19
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Elsevier
SN  - 1748-717X
KW  - Early breast cancer
KW  - Adjuvant radiotherapy
KW  - Surgical bed
KW  - APBI
KW  - External beam radiotherapy
UR  - https://ro-journal.biomedcentral.com/articles/10.1186/s13014-024-02412-x
N2  - gt;= 2 late skin toxicity was observed (p = 0.026). Late toxicity in the breast area (deformation, edema, fibrosis, and pain), affecting the quality of life and cosmetic effect, occurred in 61% and 17% of patients in WBI and APBI arms, respectively. The cosmetic effect was more favorable in the APBI arm, especially 6 to 12 months after the radiotherapy.ConclusionExternal APBI demonstrated better feasibility and less toxicity than the standard regimen in the adjuvant setting for treating early breast cancer patients. The presented study confirmed the level of evidence for establishing the external APBI in daily clinical practice.Trial registrationNCT06007118.
ER  -

BURKOŇ, Petr, Iveta SELINGEROVÁ, Marek SLÁVIK, Miloš HOLÁNEK, Miroslav VRZAL, Oldřich COUFAL, Kateřina POLÁCHOVÁ, Petr MULLER, Pavel ŠLAMPA a Tomáš KAZDA. Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study. \textit{Radiation Oncology}. BMC: Elsevier, 2024, roč.~19, č.~1, s.~1-12. ISSN~1748-717X. Dostupné z: https://dx.doi.org/10.1186/s13014-024-02412-x.