Přehled o publikaci
2024
Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
GARCIA-BORJA, Elena, František SIEGL, Rosana MATEU, Ondřej SLABÝ, Aleksi SEDO et. al.Basic information
Original name
Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
Authors
GARCIA-BORJA, Elena, František SIEGL (203 Czech Republic, belonging to the institution), Rosana MATEU, Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Aleksi SEDO (203 Czech Republic), Petr BUSEK (203 Czech Republic) and Jiří ŠÁNA (203 Czech Republic, guarantor, belonging to the institution)
Edition
BIOMARKER RESEARCH, LONDON, BMC, 2024, 2050-7771
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
is not subject to a state or trade secret
References:
RIV identification code
RIV/00216224:14110/24:00136172
Organization
Lékařská fakulta – Repository – Repository
UT WoS
001155019100001
EID Scopus
2-s2.0-85183690921
Keywords in English
PIWI-interacting RNAs; piRNAs; PIWI proteins; Cancer stem cells; Cancer
Links
LM2015064, research and development project. LX22NPO5102, research and development project. NV19-03-00501, research and development project.
Changed: 10/6/2025 00:50, RNDr. Daniel Jakubík
Abstract
V originále
Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.
