Přehled o publikaci
2024
Treponema pallidum subsp. pallidum strains DAL-1 and Philadelphia 1 differ in generation times in vitro as well as during experimental rabbit infection
BOSÁK, Juraj; Lenka MIKALOVÁ; Matěj HRALA; Petra POSPÍŠILOVÁ; Martin FALDYNA et. al.Basic information
Original name
Treponema pallidum subsp. pallidum strains DAL-1 and Philadelphia 1 differ in generation times in vitro as well as during experimental rabbit infection
Authors
BOSÁK, Juraj; Lenka MIKALOVÁ; Matěj HRALA; Petra POSPÍŠILOVÁ; Martin FALDYNA and David ŠMAJS
Edition
PLoS ONE, San Francisco, Public Library of Science, 2024, 1932-6203
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
Organization
Lékařská fakulta – Repository – Repository
UT WoS
001276406500058
EID Scopus
2-s2.0-85194196334
Keywords in English
Treponema pallidum subsp. pallidum
Links
GA23-07021S, research and development project. LX22NPO5103, research and development project.
Changed: 20/3/2025 00:51, RNDr. Daniel Jakubík
Abstract
V originále
lt; 0.01). To minimize the confounding conditions during rabbit experiments, the growth characteristics of DAL-1 and Philadelphia 1 strains were determined during TPA co-infection of rabbit testes (n = 20, including controls). During two weeks of intratesticular co-infection, DAL-1 overgrew Philadelphia 1 in all twelve testes, regardless of inoculation ratio and dose (median of relative excess DAL-1 multiplication = 84.85×). Moreover, higher DAL-1 to Philadelphia 1 inoculum ratios appeared to increase differences in growth rates, suggesting direct competition between strains for available nutrients during co-infection. These experiments indicate important physiological differences between the two TPA strains and suggest growth differences between Nichols-like and SS14-like strains that are potentially linked to their virulence and pathogenicity.
