2023
5′-UTR mRNA splicing determines CD20 levels
MRÁZ, MarekBasic information
Original name
5′-UTR mRNA splicing determines CD20 levels
Authors
MRÁZ, Marek
Edition
2023
Publisher
American Society of Hematology
Other information
Language
English
Type of outcome
Article in a journal (not reviewed)
Country of publisher
United States of America
Confidentiality degree
is not subject to a state or trade secret
References:
Organization
Středoevropský technologický institut – Repository – Repository
UT WoS
001118816600001
EID Scopus
2-s2.0-85175834117
Keywords in English
chronic lymphocytic leukemia; CD20 messenger RNA; alternative splicing; malignant B cells; anti-CD20 therapies
Links
LX22NPO5102, research and development project.
Changed: 28/3/2024 04:03, RNDr. Daniel Jakubík
Abstract
V originále
In this issue of Blood, Ang et al(1) show that human CD20 messenger RNA (mRNA) undergoes alternative splicing to generate distinct 5' untranslated region (5'-UTR) variants, which determine the cell-surface CD20 levels in malignant B cells and the interpatient variability in the expression of this therapeutic target. These variants can also be used as an escape mechanism from anti-CD20 therapies.
