FARIA ZENI, Pedro, Michaela MEDKOVÁ, K. TRACHTOVÁ, L. JANSKÁ, Václav ŠEDA, Eva HOFERKOVÁ, Nandan Mysore VARADARAJAN, Sonali SHARMA, Aleš OBRDLÍK, Štěpánka VAŇÁČOVÁ, A. MAIQUES-DIAZ, JI. MARTÍN-SUBERO and Marek MRÁZ. The role of long non-coding RNAs in BCR-mediated CLL activation. In CEITEC PhD Conference, Brno. 2023.
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Basic information
Original name The role of long non-coding RNAs in BCR-mediated CLL activation.
Authors FARIA ZENI, Pedro, Michaela MEDKOVÁ, K. TRACHTOVÁ, L. JANSKÁ, Václav ŠEDA, Eva HOFERKOVÁ, Nandan Mysore VARADARAJAN, Sonali SHARMA, Aleš OBRDLÍK, Štěpánka VAŇÁČOVÁ, A. MAIQUES-DIAZ, JI. MARTÍN-SUBERO and Marek MRÁZ.
Edition CEITEC PhD Conference, Brno, 2023.
Other information
Original language English
Type of outcome Konferenční abstrakta
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Středoevropský technologický institut – Repository – Repository
Keywords in English B cell Receptor; chronic lymphocytic leukemia; BCR inhibitors; non-coding RNAs
Links LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo. MUNI/A/1330/2021, interní kód Repo. NU23-08-00448, research and development project. 802644, interní kód Repo.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 28/3/2024 04:03.
Abstract
B cell Receptor (BCR) plays a pivotal role in providing maturation and survival signals for B cells. However, dysregulation of the BCR pathway is a fundamental characteristic observed in numerous B cell malignancies, including chronic lymphocytic leukemia (CLL), revealing its importance in disease progression. Despite the absence of recurrent mutations found in the BCR-related genes of untreated cases, BCR inhibitors have shown a universal clinical response in CLL patients. We and others have shown that short non-coding RNAs, namely microRNAs, can (dys)regulate the BCR signaling propensity, but it is still unclear if long non-coding RNAs (lncRNAs) play a role in BCRactivation. Hence, we hypothesized that lncRNAs could be involved in BCR-mediated CLL activation. To address our hypothesis, we performed differential lncRNA expression analysis in CLL cells from patients treated with BCR inhibitors and cross-validated in CLL intraclonal subpopulations with high BCR activity (CXCR4dim CD5bright) vs. low BCR activity (CXCR4bright CD5dim). We found 12 lncRNAs related to the BCR pathway inhibition/activity. Out of these lncRNAs, we selected a lncRNA that belongs to a class of lncRNA called long intergenic non-coding RNA (lincRNAs) which often play a role in trans-activating signaling pathways.
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