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@proceedings{60432,
author = {Faria Zeni, Pedro and Medková, Michaela and Trachtová, K. and Janská, L. and Šeda, Václav and Hoferková, Eva and Varadarajan, Nandan Mysore and Sharma, Sonali and Obrdlík, Aleš and Vaňáčová, Štěpánka and MaiquesandDiaz, A. and MartínandSubero, JI. and Mráz, Marek},
booktitle = {CEITEC PhD Conference, Brno},
keywords = {B cell Receptor; chronic lymphocytic leukemia; BCR inhibitors; non-coding RNAs},
language = {eng},
title = {The role of long non-coding RNAs in BCR-mediated CLL activation.},
url = {https://www.ceitec.eu/ceitec-phd-conference-2023/a4489},
year = {2023}
}
TY - CONF
ID - 60432
AU - Faria Zeni, Pedro - Medková, Michaela - Trachtová, K. - Janská, L. - Šeda, Václav - Hoferková, Eva - Varadarajan, Nandan Mysore - Sharma, Sonali - Obrdlík, Aleš - Vaňáčová, Štěpánka - Maiques-Diaz, A. - Martín-Subero, JI. - Mráz, Marek
PY - 2023
TI - The role of long non-coding RNAs in BCR-mediated CLL activation.
KW - B cell Receptor
KW - chronic lymphocytic leukemia
KW - BCR inhibitors
KW - non-coding RNAs
UR - https://www.ceitec.eu/ceitec-phd-conference-2023/a4489
N2 - B cell Receptor (BCR) plays a pivotal role in providing maturation and survival signals for B cells. However, dysregulation of the BCR pathway is a fundamental characteristic observed in numerous B cell malignancies, including chronic lymphocytic leukemia (CLL), revealing its importance in disease progression. Despite the absence of recurrent mutations found in the BCR-related genes of untreated cases, BCR inhibitors have shown a universal clinical response in CLL patients. We and others have shown that short non-coding RNAs, namely microRNAs, can (dys)regulate the BCR signaling propensity, but it is still unclear if long non-coding RNAs (lncRNAs) play a role in BCRactivation. Hence, we hypothesized that lncRNAs could be involved in BCR-mediated CLL activation. To address our hypothesis, we performed differential lncRNA expression analysis in CLL cells from patients treated with BCR inhibitors and cross-validated in CLL intraclonal subpopulations with high BCR activity (CXCR4dim CD5bright) vs. low BCR activity (CXCR4bright CD5dim). We found 12 lncRNAs related to the BCR pathway inhibition/activity. Out of these lncRNAs, we selected a lncRNA that belongs to a class of lncRNA called long intergenic non-coding RNA (lincRNAs) which often play a role in trans-activating signaling pathways.
ER -
FARIA ZENI, Pedro, Michaela MEDKOVÁ, K. TRACHTOVÁ, L. JANSKÁ, Václav ŠEDA, Eva HOFERKOVÁ, Nandan Mysore VARADARAJAN, Sonali SHARMA, Aleš OBRDLÍK, Štěpánka VAŇÁČOVÁ, A. MAIQUES-DIAZ, JI. MARTÍN-SUBERO a Marek MRÁZ. The role of long non-coding RNAs in BCR-mediated CLL activation. In \textit{CEITEC PhD Conference, Brno}. 2023.
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