Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation
sequencing data analysis and visualization in hematological
malignancies.

CSLog in Log in (EduId)

Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and ...

Přehled o publikaci

a 2023

Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.

PORC, Jakub Paweł, Tomáš REIGL, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL et. al.

Basic information

Original name

Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.

Authors

PORC, Jakub Paweł, Tomáš REIGL, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL, Kamila STRÁNSKÁ, Jana KOTAŠKOVÁ and Šárka POSPÍŠILOVÁ

Edition

EMBL Conference Cancer Genomics 2023, Heidelberg, Německo, 2023

Other information

Language

English

Type of outcome

Konferenční abstrakta

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Středoevropský technologický institut – Repository – Repository

Keywords in English

Next-generation sequencing; targeted NGS panel LYNX; cancer genomics

Links

LM2018140, research and development project. LX22NPO5102, research and development project. NU21-08-00237, research and development project. NU22-08-00227, research and development project.

Changed: 27/3/2024 04:12, RNDr. Daniel Jakubík

Abstract

V originále

Next-generation sequencing (NGS) is rapidly advancing technology in cancer genomics. The single NGS experiment can replace several laboratory tests and provide requested information about the tumor samples. However, new requirements for bioinformatic tools and computational resources are emerging in diagnostics and research. Following the development of an integrative, targeted NGS panel LYNX, enabling the detection of genetic markers recurring in lymphoid malignancies (PMID: 34082072), we focused on designing a LYNX bioinformatics tool, featuring all necessary analytical steps as well as a user interface (UI) for easy data representation and interpretation. State-of-the art resources were used to achieve our goal, such as React.js, D3.js visualisation library, Integrated Genome Browser and GATK industry standard variant calling pipeline.

Cite

PORC, Jakub Paweł, Tomáš REIGL, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL, Kamila STRÁNSKÁ, Jana KOTAŠKOVÁ and Šárka POSPÍŠILOVÁ. Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies. In EMBL Conference Cancer Genomics 2023, Heidelberg, Německo. 2023.

@proceedings{60426,
   author = {Porc, Jakub Paweł and Reigl, Tomáš and Navrkalová, Veronika and Hynšt, Jakub and Pál, Karol and Stránská, Kamila and Kotašková, Jana and Pospíšilová, Šárka},
   booktitle = {EMBL Conference Cancer Genomics 2023, Heidelberg, Německo},
   keywords = {Next-generation sequencing; targeted NGS panel LYNX; cancer genomics},
   language = {eng},
   title = {Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.},
   url = {https://www.embl.org/about/info/course-and-conference-office/events/can23-01/#vf-tabs__section-programme},
   year = {2023}
}

TY  - CONF
ID  - 60426
AU  - Porc, Jakub Paweł - Reigl, Tomáš - Navrkalová, Veronika - Hynšt, Jakub - Pál, Karol - Stránská, Kamila - Kotašková, Jana - Pospíšilová, Šárka
PY  - 2023
TI  - Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies.
KW  - Next-generation sequencing
KW  - targeted NGS panel LYNX
KW  - cancer genomics
UR  - https://www.embl.org/about/info/course-and-conference-office/events/can23-01/#vf-tabs__section-programme
N2  - Next-generation sequencing (NGS) is rapidly advancing technology in cancer genomics. The single NGS experiment can replace several laboratory tests and provide requested information about the tumor samples. However, new requirements for bioinformatic tools and computational resources are emerging in diagnostics and research. Following the development of an integrative, targeted NGS panel LYNX, enabling the detection of genetic markers recurring in lymphoid malignancies (PMID: 34082072), we focused on designing a LYNX bioinformatics tool, featuring all necessary analytical steps as well as a user interface (UI) for easy data representation and interpretation. State-of-the art resources were used to achieve our goal, such as React.js, D3.js visualisation library, Integrated Genome Browser and GATK industry standard variant calling pipeline.
ER  -

PORC, Jakub Paweł, Tomáš REIGL, Veronika NAVRKALOVÁ, Jakub HYNŠT, Karol PÁL, Kamila STRÁNSKÁ, Jana KOTAŠKOVÁ and Šárka POSPÍŠILOVÁ. Web-based bioinformatic tool LYNX: LYmphoid NeXt-generation sequencing data analysis and visualization in hematological malignancies. In \textit{EMBL Conference Cancer Genomics 2023, Heidelberg, Německo}. 2023.