Detailed Information on Publication Record

@proceedings{60356,
   author = {Pešová, Michaela and Mančíková, Veronika and Helma, Robert and Pavlová, Šárka and Hejret, Václav and Tauš, Petr and Hynšt, Jakub and Plevová, Karla and Kotašková, Jana and Malčíková, Jitka and Pospíšilová, Šárka},
   booktitle = {PhD and PostDoc RETREAT, Sněžné, Milovy},
   keywords = {Protein p53; tumor suppression; chronic lymphocytic leukemia;},
   language = {eng},
   title = {Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.},
   url = {https://www.ceitec.eu/ceitec-postdoc-phd-retreat/a4548},
   year = {2023}
}

TY  - CONF
ID  - 60356
AU  - Pešová, Michaela - Mančíková, Veronika - Helma, Robert - Pavlová, Šárka - Hejret, Václav - Tauš, Petr - Hynšt, Jakub - Plevová, Karla - Kotašková, Jana - Malčíková, Jitka - Pospíšilová, Šárka
PY  - 2023
TI  - Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function.
KW  - Protein p53
KW  - tumor suppression
KW  - chronic lymphocytic leukemia;
UR  - https://www.ceitec.eu/ceitec-postdoc-phd-retreat/a4548
N2  - Protein p53 has a central role in tumor suppression. Under normal conditions, p53 levels are kept low, but in response to DNA damage, p53 becomes stabilized and initiates the transcription of its target genes. In chronic lymphocytic leukemia (CLL), aberrations in the TP53 gene are associated with the aggressive disease since the function of p53 protein is impaired. However, the p53 function might also be disrupted by other mechanisms, e.g. altered phosphorylation, even in the wild-type protein. Therefore, we aimed to investigate the impact of p53 phosphorylation on p53 function in CLL and uncover what underlies the existence of possible different phosphorylation patterns.
ER  - 

PEŠOVÁ, Michaela, Veronika MANČÍKOVÁ, Robert HELMA, Šárka PAVLOVÁ, Václav HEJRET, Petr TAUŠ, Jakub HYNŠT, Karla PLEVOVÁ, Jana KOTAŠKOVÁ, Jitka MALČÍKOVÁ and Šárka POSPÍŠILOVÁ. Distinct p53 Phosphorylation Patterns in Chronic Lymphocytic Leukemia: Where They Come from and How They Affect p53 Function. In \textit{PhD and PostDoc RETREAT, Sněžné, Milovy}. 2023.