Clonal competition and disrupted molecular processes in chronic
lymphocytic leukemia.

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Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.

Přehled o publikaci

a 2023

Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.

ZÁVACKÁ, Kristýna, Petr TAUŠ, Karol PÁL, Jakub Paweł PORC, Šárka PAVLOVÁ et. al.

Basic information

Original name

Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.

Authors

Edition

XXVIIth Biochemistry congress, 2023

Other information

Language

English

Type of outcome

Konferenční abstrakta

Country of publisher

Slovakia

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Středoevropský technologický institut – Repository – Repository

ISBN

978-80-8240-048-2

Keywords in English

Chronic lymphocytic leukemia; TP53 gene;

Links

LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo. NU21-08-00237, research and development project.

Changed: 25/3/2024 03:21, RNDr. Daniel Jakubík

Abstract

V originále

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. Due to dynamic clonal changes in a leukemic cell population over time, CLL is characterized by a highly variable clinical course. The expansion of subclones with different gene mutations, many of which are non-recurrent, makes CLL challenging to treat. We aimed to describe the clonal evolution in CLL, focusing on specific treatments and different stages of the disease. As defects in the TP53 gene are strong predictive and prognostic markers in CLL and drive chemoimmunotherapy resistance, we particularly studied factors influencing the clonal development of TP53-mutated subclones.

Files attached

https://is.muni.cz/publication/2317919/FEBS-Biochemistry_Congress_final_programme_abstract_book.pdf

Cite

ZÁVACKÁ, Kristýna, Petr TAUŠ, Karol PÁL, Jakub Paweł PORC, Šárka PAVLOVÁ, Jitka MALČÍKOVÁ, Kamila STRÁNSKÁ, Marcela ŽENATOVÁ, Boris TICHÝ, Nicolas BLAVET, Anna PANOVSKÁ, Michael DOUBEK, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ. Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia. In XXVIIth Biochemistry congress. 2023. ISBN 978-80-8240-048-2.

@proceedings{60352,
   author = {Závacká, Kristýna and Tauš, Petr and Pál, Karol and Porc, Jakub Paweł and Pavlová, Šárka and Malčíková, Jitka and Stránská, Kamila and Ženatová, Marcela and Tichý, Boris and Blavet, Nicolas and Panovská, Anna and Doubek, Michael and Pospíšilová, Šárka and Plevová, Karla},
   booktitle = {XXVIIth Biochemistry congress},
   keywords = {Chronic lymphocytic leukemia; TP53 gene;},
   language = {eng},
   isbn = {978-80-8240-048-2},
   title = {Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.},
   url = {https://ssbmb2023.sk/content/19-programme},
   year = {2023}
}

TY  - CONF
ID  - 60352
AU  - Závacká, Kristýna - Tauš, Petr - Pál, Karol - Porc, Jakub Paweł - Pavlová, Šárka - Malčíková, Jitka - Stránská, Kamila - Ženatová, Marcela - Tichý, Boris - Blavet, Nicolas - Panovská, Anna - Doubek, Michael - Pospíšilová, Šárka - Plevová, Karla
PY  - 2023
TI  - Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.
SN  - 9788082400482
KW  - Chronic lymphocytic leukemia
KW  - TP53 gene;
UR  - https://ssbmb2023.sk/content/19-programme
N2  - Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. Due to dynamic clonal changes in a leukemic cell population over time, CLL is characterized by a highly variable clinical course. The expansion of subclones with different gene mutations, many of which are non-recurrent, makes CLL challenging to treat. We aimed to describe the clonal evolution in CLL, focusing on specific treatments and different stages of the disease. As defects in the TP53 gene are strong predictive and prognostic markers in CLL and drive chemoimmunotherapy resistance, we particularly studied factors influencing the clonal development of TP53-mutated subclones.
ER  -

ZÁVACKÁ, Kristýna, Petr TAUŠ, Karol PÁL, Jakub Paweł PORC, Šárka PAVLOVÁ, Jitka MALČÍKOVÁ, Kamila STRÁNSKÁ, Marcela ŽENATOVÁ, Boris TICHÝ, Nicolas BLAVET, Anna PANOVSKÁ, Michael DOUBEK, Šárka POSPÍŠILOVÁ and Karla PLEVOVÁ. Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia. In \textit{XXVIIth Biochemistry congress}. 2023. ISBN~978-80-8240-048-2.