Podrobný výpis o publikaci

@proceedings{60349,
   author = {Ondrišová, Laura and Šeda, Václav and Hoferková, Eva and Chiodin, G. and Hlaváč, Kryštof and Košťálová, Lenka and Mladonická Pavlasová, Gabriela and Filip, Daniel and Faria Zeni, Pedro and Oppelt, Jan and Panovská, Anna and Plevová, Karla and Pospíšilová, Šárka and Simkovic, M. and Vrbacký, F. and Lysák, Daniel and Fernandes, SM. and Davids, MS. and MaiquesandDiaz, A. and Charalampopoulou, S. and MartinandSubero, JI. and Brown, JR. and Doubek, Michael and Forconi, F. and Mayer, Jiří and Mráz, Marek},
   booktitle = {ICML, Švýcarsko, Lugano},
   keywords = {BCR inhibitors; CLL; PI3K‐Akt activation},
   language = {eng},
   title = {FOX01-rictor AXIS induces AKT phosporylation during CLL cell adaptation to BCR inhibitors: Implications for combinatorial therapy.},
   url = {https://www.icml.ch/icml/home.html},
   year = {2023}
}

TY  - CONF
ID  - 60349
AU  - Ondrišová, Laura - Šeda, Václav - Hoferková, Eva - Chiodin, G. - Hlaváč, Kryštof - Košťálová, Lenka - Mladonická Pavlasová, Gabriela - Filip, Daniel - Faria Zeni, Pedro - Oppelt, Jan - Panovská, Anna - Plevová, Karla - Pospíšilová, Šárka - Simkovic, M. - Vrbacký, F. - Lysák, Daniel - Fernandes, SM. - Davids, MS. - Maiques-Diaz, A. - Charalampopoulou, S. - Martin-Subero, JI. - Brown, JR. - Doubek, Michael - Forconi, F. - Mayer, Jiří - Mráz, Marek
PY  - 2023
TI  - FOX01-rictor AXIS induces AKT phosporylation during CLL cell adaptation to BCR inhibitors: Implications for combinatorial therapy.
KW  - BCR inhibitors
KW  - CLL
KW  - PI3K‐Akt activation
UR  - https://www.icml.ch/icml/home.html
N2  - Although genetic mechanisms of resistance to BCR inhibitors in CLL are well‐known, it remains elusive whether non genetic adaptation mechanisms might exist. We focused on the possible role of Akt pathway as PI3K‐Akt activation is the only known factor that rescues the apoptosis induced by BCR deletionin mature Bcells in mouse models. We performed transcriptome profiling (Illumina) and analyzed samples obtained from CLL patients before andduring ibrutinib or idelalisib therapy (1–12weeks of therapy, n=70 patients with 194samples) and performed gene editing in MEC1 cells to reveal the functional role of FoxO1/Rictor.
ER  - 

ONDRIŠOVÁ, Laura, Václav ŠEDA, Eva HOFERKOVÁ, G. CHIODIN, Kryštof HLAVÁČ, Lenka KOŠŤÁLOVÁ, Gabriela MLADONICKÁ PAVLASOVÁ, Daniel FILIP, Pedro FARIA ZENI, Jan OPPELT, Anna PANOVSKÁ, Karla PLEVOVÁ, Šárka POSPÍŠILOVÁ, M. SIMKOVIC, F. VRBACKÝ, Daniel LYSÁK, SM. FERNANDES, MS. DAVIDS, A. MAIQUES-DIAZ, S. CHARALAMPOPOULOU, JI. MARTIN-SUBERO, JR. BROWN, Michael DOUBEK, F. FORCONI, Jiří MAYER a Marek MRÁZ. FOX01-rictor AXIS induces AKT phosporylation during CLL cell adaptation to BCR inhibitors: Implications for combinatorial therapy. In \textit{ICML, Švýcarsko, Lugano}. 2023.