KURUCOVÁ, Terézia, Kamila RÉBLOVÁ, Martina VALIŠOVÁ, Jakub Paweł PORC, Veronika NAVRKALOVÁ, Šárka PAVLOVÁ, Jitka MALČÍKOVÁ, Karla PLEVOVÁ, Boris TICHÝ, Michael DOUBEK, Jana KOTAŠKOVÁ and Šárka POSPÍŠILOVÁ. Single-cell RNA-sequencing enables tracking and characterization of rare CLL cells with the potential to cause refractoriness. In EHA 2023 in HemaSphere (2023). 2023. ISSN 2572-9241.
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Basic information
Original name Single-cell RNA-sequencing enables tracking and characterization of rare CLL cells with the potential to cause refractoriness.
Authors KURUCOVÁ, Terézia, Kamila RÉBLOVÁ, Martina VALIŠOVÁ, Jakub Paweł PORC, Veronika NAVRKALOVÁ, Šárka PAVLOVÁ, Jitka MALČÍKOVÁ, Karla PLEVOVÁ, Boris TICHÝ, Michael DOUBEK, Jana KOTAŠKOVÁ and Šárka POSPÍŠILOVÁ.
Edition EHA 2023 in HemaSphere (2023), 2023.
Other information
Original language English
Type of outcome Konferenční abstrakta
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization Středoevropský technologický institut – Repository – Repository
ISSN 2572-9241
Keywords in English Chronic lymphocytic leukemia; single-cell RNA sequencing; relapse
Links LX22NPO5102, research and development project. MUNI/A/1224/2022, interní kód Repo. NU20-08-00314, research and development project.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 25/3/2024 03:21.
Abstract
Chronic lymphocytic leukemia (CLL) is considered an incurable disease due to the limited ability of current treatment options to completely eradicate leukemic cells. The therapy selection pressure favors the preferential proliferation of rare resistant cells, leading to recurrent relapses. Early detection of these rare cells holds the potential to assist in selecting appropriate therapy. To explore the possibility to identify and characterize rare populations of CLL cells resistant to treatment and causing relapses, and trace the presence of such cells during the disease course by single-cell RNA sequencing (scRNA-seq).
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