This special issue was envisaged to cover diverse scholarly contributions of an empirical nature that focus on various questions linked to the COVID-19 crisis in the Czech Republic and Slovakia. The choice of countries was intentional; after all, the Czech Republic and Slovakia both experienced controversial developments during 2020. The COVID-19 pandemic found them unprepared and inexperienced in the field of serious epidemics yet also saw them gain international recognition for the very positive results gained from their initial responses. The second half of 2020 provided a very different story. Both countries were hard hit by the epidemics immediately after the summer, and the situation worsened month by month. These negative developments escalated at the end of 2020 and in early 2021 when the number of new cases rapidly increased and the total number of patients at risk of dying began to exceed the capacities of public hospitals. This summary offers an overview of the research by authors included in this special issue. It compares their findings with the results of others in order to suggest a set of policy implications that are based on empirical analyses. There is also an attempt to estimate several avenues of further multi-disciplinary research focusing on the COVID-19 pandemic and relevant policy responses. Within this context, this special issue is useful for both researchers and policy makers.