Genetic risk score in patients with the APOE2/E2 genotype as a
predictor of familial dysbetalipoproteinemia

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Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial ...

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J 2024

Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia

SATNY, Martin, Veronika TODOROVOVA, Tereza ALTSCHMIEDOVA, Jaroslav A HUBACEK, Lucie DLOUHA et. al.

Basic information

Original name

Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia

Authors

SATNY, Martin, Veronika TODOROVOVA, Tereza ALTSCHMIEDOVA, Jaroslav A HUBACEK, Lucie DLOUHA, Vera LANSKA, Vladimír SOŠKA, Ondřej KYSELÁK, Tomáš FREIBERGER, Martin BOBÁK and Michal VRABLIK

Edition

Journal of Clinical Lipidology, NEW YORK, ELSEVIER SCIENCE INC, 2024, 1933-2874

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Lékařská fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1016/j.jacl.2023.11.010

UT WoS

001239945500003

EID Scopus

2-s2.0-85178638779

Keywords in English

Familial dysbetalipoproteinemia; Cardiovascular risk; Polymorphism; Genetic risk score

Links

LX22NPO5104, research and development project.

Changed: 10/7/2024 04:59, RNDr. Daniel Jakubík

Abstract

V originále

lt; 0.0005). Conclusions We identified several SNPs that are individual additive factors influencing FD development. The use of unweighted GRS2 is a simple and clinically relevant tool that further improves the prediction of FD in APOE2/E2 homozygotes with corresponding biochemical characteristics.

Files attached

https://is.muni.cz/publication/2374298/Genetic_risk_score_in_patients_with_the_APOE2_E2_genotype_as_a_predictor_of_familial_dysbetalipoproteinemia.pdf

https://is.muni.cz/publication/2374298/Genetic_risk_score_in_patients_with_the_APOE2_E2_genotype_as_a_predictor_of_familial_dysbetalipoproteinemia_dmeljbco.pdf

Cite

SATNY, Martin, Veronika TODOROVOVA, Tereza ALTSCHMIEDOVA, Jaroslav A HUBACEK, Lucie DLOUHA, Vera LANSKA, Vladimír SOŠKA, Ondřej KYSELÁK, Tomáš FREIBERGER, Martin BOBÁK and Michal VRABLIK. Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia. Journal of Clinical Lipidology. NEW YORK: ELSEVIER SCIENCE INC, 2024, vol. 18, No 2, p. "e230"-"e237", 8 pp. ISSN 1933-2874. Available from: https://dx.doi.org/10.1016/j.jacl.2023.11.010.

@article{59748,
   author = {Satny, Martin and Todorovova, Veronika and Altschmiedova, Tereza and Hubacek, Jaroslav A and Dlouha, Lucie and Lanska, Vera and Soška, Vladimír and Kyselák, Ondřej and Freiberger, Tomáš and Bobák, Martin and Vrablik, Michal},
   article_location = {NEW YORK},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jacl.2023.11.010},
   keywords = {Familial dysbetalipoproteinemia; Cardiovascular risk; Polymorphism; Genetic risk score},
   language = {eng},
   issn = {1933-2874},
   journal = {Journal of Clinical Lipidology},
   title = {Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia},
   url = {https://www.sciencedirect.com/science/article/pii/S1933287423003422?via%3Dihub},
   volume = {18},
   year = {2024}
}

TY  - JOUR
ID  - 59748
AU  - Satny, Martin - Todorovova, Veronika - Altschmiedova, Tereza - Hubacek, Jaroslav A - Dlouha, Lucie - Lanska, Vera - Soška, Vladimír - Kyselák, Ondřej - Freiberger, Tomáš - Bobák, Martin - Vrablik, Michal
PY  - 2024
TI  - Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia
JF  - Journal of Clinical Lipidology
VL  - 18
IS  - 2
SP  - "e230"-"e237"
EP  - "e230"-"e237"
PB  - ELSEVIER SCIENCE INC
SN  - 1933-2874
KW  - Familial dysbetalipoproteinemia
KW  - Cardiovascular risk
KW  - Polymorphism
KW  - Genetic risk score
UR  - https://www.sciencedirect.com/science/article/pii/S1933287423003422?via%3Dihub
N2  - lt; 0.0005). Conclusions We identified several SNPs that are individual additive factors influencing FD development. The use of unweighted GRS2 is a simple and clinically relevant tool that further improves the prediction of FD in APOE2/E2 homozygotes with corresponding biochemical characteristics.
ER  -

SATNY, Martin, Veronika TODOROVOVA, Tereza ALTSCHMIEDOVA, Jaroslav A HUBACEK, Lucie DLOUHA, Vera LANSKA, Vladimír SOŠKA, Ondřej KYSELÁK, Tomáš FREIBERGER, Martin BOBÁK and Michal VRABLIK. Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia. \textit{Journal of Clinical Lipidology}. NEW YORK: ELSEVIER SCIENCE INC, 2024, vol.~18, No~2, p.~''e230''-''e237'', 8 pp. ISSN~1933-2874. Available from: https://dx.doi.org/10.1016/j.jacl.2023.11.010.