2021
NMR Studies of Tau Protein in Tauopathies
KITOKA, K.; R. SKRABANA; Norbert GAŠPARIK; Jozef HRITZ; K. JAUDZEMS et. al.Basic information
Original name
NMR Studies of Tau Protein in Tauopathies
Authors
KITOKA, K.; R. SKRABANA; Norbert GAŠPARIK (703 Slovakia, belonging to the institution); Jozef HRITZ (703 Slovakia, guarantor, belonging to the institution) and K. JAUDZEMS
Edition
Frontiers in Molecular Biosciences, Lausanne, Frontiers Media SA, 2021, 2296-889X
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
Switzerland
Confidentiality degree
is not subject to a state or trade secret
References:
RIV identification code
RIV/00216224:14740/21:00123604
Organization
Středoevropský technologický institut – Repository – Repository
UT WoS
000727903000001
EID Scopus
2-s2.0-85120688263
Keywords in English
tau; nuclear magnetic resonance; protein structure; Alzheimer's disease; filaments
Links
LTAUSA18168, research and development project. 873127, interní kód Repo.
Changed: 31/1/2024 03:37, RNDr. Daniel Jakubík
Abstract
V originále
Tauopathies, including Alzheimer's disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has become an appealing target for therapy. Current knowledge of the pathological effects and significance of specific species in the tau aggregation pathway is incomplete although more and more structural and mechanistic insights are being gained using biophysical techniques. Here, we review the application of NMR to structural studies of various tau forms that appear in its aggregation process, focusing on results obtained from solid-state NMR. Furthermore, we discuss implications from these studies and their prospective contribution to the development of new tauopathy therapies.
