Intestinal Paneth cell differentiation relies on asymmetric
regulation of Wnt signaling by Daam1/2

Přehled o publikaci

J 2023

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

COLOZZA, Gabriele; Heetak LEE; Alessandra MERENDA; Sam Wu SZU-HSIEN; Andrea CATALÀ-BORDES et al.

Základní údaje

Originální název

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

Autoři

Vydání

Science Advances, Washington, DC, American association for the advancement of science, 2023, 2375-2548

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00132483

Organizace

Přírodovědecká fakulta – Masarykova univerzita – Repozitář

Klíčová slova anglicky

CONVERGENT EXTENSION; WNT/BETA-CATENIN; ENDOCYTOSIS; RECEPTORS; PROTEINS; ACTIVATION; GROWTH; LGR5; RHO

Návaznosti

GX19-28347X, projekt VaV. LM2023050, projekt VaV. LX22NPO5102, projekt VaV.

Změněno: 26. 4. 2024 04:07, RNDr. Daniel Jakubík

Anotace

V originále

The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom. Paneth cells form a major element of the niche microenvironment providing various growth factors to orchestrate intestinal stem cell homeostasis, such as Wnt3. Different Wnt ligands can selectively activate β-catenin–dependent (canonical) or –independent (noncanonical) signaling. Here, we report that the Dishevelled-associated activator of morphogenesis 1 (Daam1) and its paralogue Daam2 asymmetrically regulate canonical and noncanonical Wnt (Wnt/PCP) signaling. Daam1/2 interacts with the Wnt inhibitor RNF43, and Daam1/2 double knockout stimulates canonical Wnt signaling by preventing RNF43-dependent degradation of the Wnt receptor, Frizzled (Fzd). Single-cell RNA sequencing analysis revealed that Paneth cell differentiation is impaired by Daam1/2 depletion because of defective Wnt/PCP signaling. Together, we identified Daam1/2 as an unexpected hub molecule coordinating both canonical and noncanonical Wnt, which is fundamental for specifying an adequate number of Paneth cells.

Přiložené soubory

https://is.muni.cz/publication/2348565/Intestinal_Paneth_cell_differentiation_relies_on_asymmetric_regulation_of_Wnt_signaling_by_Daam1_2.pdf

Citovat

COLOZZA, Gabriele; Heetak LEE; Alessandra MERENDA; Sam Wu SZU-HSIEN; Andrea CATALÀ-BORDES; Tomasz Witold RADASZKIEWICZ; Ingrid JORDENS; Lee JI-HYUN; Bamford AILEEN-DIANE; Fiona FARNHAMMER; Teck Yew LOW; Madelon M MAURICE; Vítězslav BRYJA; Jihoon KIM a Koo BON-KYOUNG. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Science Advances. Washington, DC: American association for the advancement of science, 2023, roč. 9, č. 47, s. 1-18. ISSN 2375-2548. Dostupné z: https://doi.org/10.1126/sciadv.adh9673.

@article{58695,
   author = {Colozza, Gabriele and Lee, Heetak and Merenda, Alessandra and SzuandHsien, Sam Wu and CatalàandBordes, Andrea and Radaszkiewicz, Tomasz Witold and Jordens, Ingrid and JiandHyun, Lee and AileenandDiane, Bamford and Farnhammer, Fiona and Low, Teck Yew and Maurice, Madelon M and Bryja, Vítězslav and Kim, Jihoon and BonandKyoung, Koo},
   article_location = {Washington, DC},
   article_number = {47},
   doi = {https://doi.org/10.1126/sciadv.adh9673},
   keywords = {CONVERGENT EXTENSION; WNT/BETA-CATENIN; ENDOCYTOSIS; RECEPTORS; PROTEINS; ACTIVATION; GROWTH; LGR5; RHO},
   language = {eng},
   issn = {2375-2548},
   journal = {Science Advances},
   title = {Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2},
   url = {https://www.science.org/doi/10.1126/sciadv.adh9673},
   volume = {9},
   year = {2023}
}

TY  - JOUR
ID  - 58695
AU  - Colozza, Gabriele - Lee, Heetak - Merenda, Alessandra - Szu-Hsien, Sam Wu - Català-Bordes, Andrea - Radaszkiewicz, Tomasz Witold - Jordens, Ingrid - Ji-Hyun, Lee - Aileen-Diane, Bamford - Farnhammer, Fiona - Low, Teck Yew - Maurice, Madelon M - Bryja, Vítězslav - Kim, Jihoon - Bon-Kyoung, Koo
PY  - 2023
TI  - Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2
JF  - Science Advances
VL  - 9
IS  - 47
SP  - 1-18
EP  - 1-18
PB  - American association for the advancement of science
SN  - 2375-2548
KW  - CONVERGENT EXTENSION
KW  - WNT/BETA-CATENIN
KW  - ENDOCYTOSIS
KW  - RECEPTORS
KW  - PROTEINS
KW  - ACTIVATION
KW  - GROWTH
KW  - LGR5
KW  - RHO
UR  - https://www.science.org/doi/10.1126/sciadv.adh9673
N2  - The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom. Paneth cells form a major element of the niche microenvironment providing various growth factors to orchestrate intestinal stem cell homeostasis, such as Wnt3. Different Wnt ligands can selectively activate β-catenin–dependent (canonical) or –independent (noncanonical) signaling. Here, we report that the Dishevelled-associated activator of morphogenesis 1 (Daam1) and its paralogue Daam2 asymmetrically regulate canonical and noncanonical Wnt (Wnt/PCP) signaling. Daam1/2 interacts with the Wnt inhibitor RNF43, and Daam1/2 double knockout stimulates canonical Wnt signaling by preventing RNF43-dependent degradation of the Wnt receptor, Frizzled (Fzd). Single-cell RNA sequencing analysis revealed that Paneth cell differentiation is impaired by Daam1/2 depletion because of defective Wnt/PCP signaling. Together, we identified Daam1/2 as an unexpected hub molecule coordinating both canonical and noncanonical Wnt, which is fundamental for specifying an adequate number of Paneth cells.
ER  -

COLOZZA, Gabriele; Heetak LEE; Alessandra MERENDA; Sam Wu SZU-HSIEN; Andrea CATALÀ-BORDES; Tomasz Witold RADASZKIEWICZ; Ingrid JORDENS; Lee JI-HYUN; Bamford AILEEN-DIANE; Fiona FARNHAMMER; Teck Yew LOW; Madelon M MAURICE; Vítězslav BRYJA; Jihoon KIM a Koo BON-KYOUNG. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. \textit{Science Advances}. Washington, DC: American association for the advancement of science, 2023, roč.~9, č.~47, s.~1-18. ISSN~2375-2548. Dostupné z: https://doi.org/10.1126/sciadv.adh9673.

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