The genomes of the yaws bacterium, Treponema pallidum subsp.
pertenue, of nonhuman primate and human origin are not
genomically distinct

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The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and ...

Přehled o publikaci

J 2023

The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct

JANEČKOVÁ, Klára; Christian ROOS; Pavla FEDROVÁ; Nikola TOM; Darina CEJKOVA et. al.

Základní údaje

Originální název

The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct

Autoři

JANEČKOVÁ, Klára; Christian ROOS; Pavla FEDROVÁ; Nikola TOM; Darina CEJKOVA; Simone LUEERT; Julius D KEYYU; Idrissa S CHUMA; Sascha KNAUF a David ŠMAJS

Vydání

PLoS neglected tropical diseases, San Francisco, Public Library of Science, 2023, 1935-2735

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizace

Lékařská fakulta – Masarykova univerzita – Repozitář

DOI

http://dx.doi.org/10.1371/journal.pntd.0011602

UT WoS

001067855700001

EID Scopus

2-s2.0-85171236178

Klíčová slova anglicky

Treponema pallidum subsp. pertenue

Návaznosti

LX22NPO5103, projekt VaV. MUNI/A/1393/2022, interní kód Repo.

Změněno: 15. 2. 2024 03:55, RNDr. Daniel Jakubík

Anotace

V originále

BackgroundTreponema pallidum subsp. pertenue (TPE) is the causative agent of human yaws. Yaws is currently reported in 13 endemic countries in Africa, southern Asia, and the Pacific region. During the mid-20th century, a first yaws eradication effort resulted in a global 95% drop in yaws prevalence. The lack of continued surveillance has led to the resurgence of yaws. The disease was believed to have no animal reservoirs, which supported the development of a currently ongoing second yaws eradication campaign. Concomitantly, genetic evidence started to show that TPE strains naturally infect nonhuman primates (NHPs) in sub-Saharan Africa. In our current study we tested hypothesis that NHP- and human-infecting TPE strains differ in the previously unknown parts of the genomes.Methodology/Principal findingsIn this study, we determined complete (finished) genomes of ten TPE isolates that originated from NHPs and compared them to TPE whole-genome sequences from human yaws patients. We performed an in-depth analysis of TPE genomes to determine if any consistent genomic differences are present between TPE genomes of human and NHP origin. We were able to resolve previously undetermined TPE chromosomal regions (sequencing gaps) that prevented us from making a conclusion regarding the sequence identity of TPE genomes from NHPs and humans. The comparison among finished genome sequences revealed no consistent differences between human and NHP TPE genomes.Conclusion/SignificanceOur data show that NHPs are infected with strains that are not only similar to the strains infecting humans but are genomically indistinguishable from them. Although interspecies transmission in NHPs is a rare event and evidence for current spillover events is missing, the existence of the yaws bacterium in NHPs is demonstrated. While the low risk of spillover supports the current yaws treatment campaign, it is of importance to continue yaws surveillance in areas where NHPs are naturally infected with TPE even if yaws is successfully eliminated in humans.

Přiložené soubory

https://is.muni.cz/publication/2336537/The_genomes_of_the_yaws_bacterium__Treponema_pallidum_subsp._pertenue__of_nonhuman_primate_and_human_origin_are_not_genomically_distinct.pdf

Citovat

JANEČKOVÁ, Klára; Christian ROOS; Pavla FEDROVÁ; Nikola TOM; Darina CEJKOVA; Simone LUEERT; Julius D KEYYU; Idrissa S CHUMA; Sascha KNAUF a David ŠMAJS. The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct. PLoS neglected tropical diseases. San Francisco: Public Library of Science, 2023, roč. 17, č. 9, s. 1-21. ISSN 1935-2735. Dostupné z: https://dx.doi.org/10.1371/journal.pntd.0011602.

@article{58206,
   author = {Janečková, Klára and Roos, Christian and Fedrová, Pavla and Tom, Nikola and Cejkova, Darina and Lueert, Simone and Keyyu, Julius D and Chuma, Idrissa S and Knauf, Sascha and Šmajs, David},
   article_location = {San Francisco},
   article_number = {9},
   doi = {http://dx.doi.org/10.1371/journal.pntd.0011602},
   keywords = {Treponema pallidum subsp. pertenue},
   language = {eng},
   issn = {1935-2735},
   journal = {PLoS neglected tropical diseases},
   title = {The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct},
   url = {https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011602},
   volume = {17},
   year = {2023}
}

TY  - JOUR
ID  - 58206
AU  - Janečková, Klára - Roos, Christian - Fedrová, Pavla - Tom, Nikola - Cejkova, Darina - Lueert, Simone - Keyyu, Julius D - Chuma, Idrissa S - Knauf, Sascha - Šmajs, David
PY  - 2023
TI  - The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct
JF  - PLoS neglected tropical diseases
VL  - 17
IS  - 9
SP  - 1-21
EP  - 1-21
PB  - Public Library of Science
SN  - 1935-2735
KW  - Treponema pallidum subsp. pertenue
UR  - https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011602
N2  - BackgroundTreponema pallidum subsp. pertenue (TPE) is the causative agent of human yaws. Yaws is currently reported in 13 endemic countries in Africa, southern Asia, and the Pacific region. During the mid-20th century, a first yaws eradication effort resulted in a global 95% drop in yaws prevalence. The lack of continued surveillance has led to the resurgence of yaws. The disease was believed to have no animal reservoirs, which supported the development of a currently ongoing second yaws eradication campaign. Concomitantly, genetic evidence started to show that TPE strains naturally infect nonhuman primates (NHPs) in sub-Saharan Africa. In our current study we tested hypothesis that NHP- and human-infecting TPE strains differ in the previously unknown parts of the genomes.Methodology/Principal findingsIn this study, we determined complete (finished) genomes of ten TPE isolates that originated from NHPs and compared them to TPE whole-genome sequences from human yaws patients. We performed an in-depth analysis of TPE genomes to determine if any consistent genomic differences are present between TPE genomes of human and NHP origin. We were able to resolve previously undetermined TPE chromosomal regions (sequencing gaps) that prevented us from making a conclusion regarding the sequence identity of TPE genomes from NHPs and humans. The comparison among finished genome sequences revealed no consistent differences between human and NHP TPE genomes.Conclusion/SignificanceOur data show that NHPs are infected with strains that are not only similar to the strains infecting humans but are genomically indistinguishable from them. Although interspecies transmission in NHPs is a rare event and evidence for current spillover events is missing, the existence of the yaws bacterium in NHPs is demonstrated. While the low risk of spillover supports the current yaws treatment campaign, it is of importance to continue yaws surveillance in areas where NHPs are naturally infected with TPE even if yaws is successfully eliminated in humans.
ER  -

JANEČKOVÁ, Klára; Christian ROOS; Pavla FEDROVÁ; Nikola TOM; Darina CEJKOVA; Simone LUEERT; Julius D KEYYU; Idrissa S CHUMA; Sascha KNAUF a David ŠMAJS. The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct. \textit{PLoS neglected tropical diseases}. San Francisco: Public Library of Science, 2023, roč.~17, č.~9, s.~1-21. ISSN~1935-2735. Dostupné z: https://dx.doi.org/10.1371/journal.pntd.0011602.