J 2023

Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus

ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA, Dušan HOLUB, Jan Sebastian NOVOTNY et. al.

Basic information

Original name

Pathogenesis of Alzheimer´s disease: Involvement of the choroid plexus

Authors

ČARNA, Maria, Isaac G. ONYANGO, Stanislav KATINA (703 Slovakia, belonging to the institution), Dušan HOLUB, Jan Sebastian NOVOTNY, Markéta NEZVEDOVÁ (203 Czech Republic, belonging to the institution), Durga JHA (356 India, belonging to the institution), Zuzana NEDELSKA, Valentina LACOVICH, Thijs Vande VYVERE, Ruben HOUBRECHTS, Krystine GARCIA-MANSFIELD, Ritin SHARMA, Victoria DAVID-DIRGO, Martin VYHNALEK, Kateřina TEXLOVA, Hernan CHAVES, Nadine BAKKAR, Lucia PERTIERRA, Mojmír VINKLER (203 Czech Republic, belonging to the institution), Hana MARKOVA, Jan LACZO, Kateřina SHEARDOVÁ (203 Czech Republic, belonging to the institution), Marcela HORTOVA-KOHOUTKOVA, Jan FRIČ, Giancarlo FORTE, Petr KAŇOVSKY, Silvie BELAŠKOVA, Jiří DAMBORSKÝ (203 Czech Republic, belonging to the institution), Jakub HORT, Nicholas T. SEYFRIED, Robert BOWSER, Gustavo SEVLEVER, Robert A. RISSMAN, Richard A. SMITH, Marian HAJDUCH, Patrick PIRROTTE, Zdeněk SPÁČIL (203 Czech Republic, belonging to the institution), Eric B. DAMMER, Clara LIMBÄCK-STOKIN and Gorazd B. STOKIN

Edition

Dementia, NEW YORK, Wiley, 2023, 1552-5260

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14310/23:00130379

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1002/alz.12970

UT WoS

000937916400001

EID Scopus

2-s2.0-85149648409

Keywords in English

aging; Alzheimer's disease; cerebrospinal fluid; choroid plexus; pathology

Links

EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. LM2018121, research and development project. LX22NPO5107, research and development project. MUNI/G/1131/2017, interní kód Repo. NV19-08-00472, research and development project. 857560, interní kód Repo.
Changed: 28/8/2024 00:50, RNDr. Daniel Jakubík

Abstract

V originále

The choroid plexus (ChP) produces and is bathed in the cerebrospinal fluid (CSF), which in aging and Alzheimer's disease (AD) shows extensive proteomic alterations including evidence of inflammation. Considering inflammation hampers functions of the involved tissues, the CSF abnormalities reported in these conditions are suggestive of ChP injury. Indeed, several studies document ChP damage in aging and AD, which nevertheless remains to be systematically characterized. We here report that the changes elicited in the CSF by AD are consistent with a perturbed aging process and accompanied by aberrant accumulation of inflammatory signals and metabolically active proteins in the ChP. Magnetic resonance imaging (MRI) imaging shows that these molecular aberrancies correspond to significant remodeling of ChP in AD, which correlates with aging and cognitive decline. Collectively, our preliminary post-mortem and in vivo findings reveal a repertoire of ChP pathologies indicative of its dysfunction and involvement in the pathogenesis of AD.
Displayed: 9/6/2025 14:40