J
2023
FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer
GRELL, Peter, Simona BOŘILOVÁ, Pavel FABIAN, Iveta SELINGEROVA, David NOVAK et. al.
Basic information
Original name
FoxP3 Expression in Tumor-Infiltrating Lymphocytes as Potential Predictor of Response to Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and Non-Small Cell Lung Cancer
Authors
GRELL, Peter, Simona BOŘILOVÁ, Pavel FABIAN, Iveta SELINGEROVA, David NOVAK, Petr MULLER, Igor KISS and Rostislav VYZULA
Edition
Cancers, BASEL, MDPI, 2023, 2072-6694
Other information
Type of outcome
Article in a journal
Country of publisher
Switzerland
Confidentiality degree
is not subject to a state or trade secret
Organization
Lékařská fakulta – Repository – Repository
Keywords in English
immune checkpoint inhibitors; anti-tumor immunity; predictive biomarker; malignant melanoma; NSCLC
Links
LX22NPO5102, research and development project. BBMRI.cz IV, large research infrastructures.
V originále
gt;= 1 (p = 0.005, HR 0.26). In the NSCLC group, only FoxP3 positivity was associated with shorter PFS and OS. We found that FoxP3 negativity was linked with a better response to ICI in both histological groups.
Displayed: 21/5/2025 13:12