All-cause and cardiovascular mortality in relation to lung
function in the full range of distribution across four Eastern
European cohorts

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All-cause and cardiovascular mortality in relation to lung function in the full range of ...

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J 2022

All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts

SARYCHEVA, Tatyana Vladimirovna, Nadezda CAPKOVA, Andrzej PAJAK, Sofia MALYUTINA, Abdonas TAMOSIUNAS et. al.

Basic information

Original name

All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts

Authors

SARYCHEVA, Tatyana Vladimirovna, Nadezda CAPKOVA, Andrzej PAJAK, Sofia MALYUTINA, Abdonas TAMOSIUNAS, Martin BOBÁK and Hynek PIKHART

Edition

Scientific Reports, London, Nature Publishing Group, 2022, 2045-2322

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1038/s41598-022-17261-5

UT WoS

000833071900069

EID Scopus

2-s2.0-85135156680

Keywords in English

PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES

Links

EF17_043/0009632, research and development project. LX22NPO5104, research and development project. 857487, interní kód Repo. 857560, interní kód Repo.

Changed: 23/9/2022 03:39, RNDr. Daniel Jakubík

Abstract

V originále

It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.

Files attached

https://is.muni.cz/publication/2218237/2218237.pdf

Cite

SARYCHEVA, Tatyana Vladimirovna, Nadezda CAPKOVA, Andrzej PAJAK, Sofia MALYUTINA, Abdonas TAMOSIUNAS, Martin BOBÁK and Hynek PIKHART. All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts. Scientific Reports. London: Nature Publishing Group, 2022, vol. 12, No 1, p. 1-9. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-17261-5.

@article{51848,
   author = {Sarycheva, Tatyana Vladimirovna and Capkova, Nadezda and Pajak, Andrzej and Malyutina, Sofia and Tamosiunas, Abdonas and Bobák, Martin and Pikhart, Hynek},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-17261-5},
   keywords = {PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts},
   url = {https://www.nature.com/articles/s41598-022-17261-5},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 51848
AU  - Sarycheva, Tatyana Vladimirovna - Capkova, Nadezda - Pajak, Andrzej - Malyutina, Sofia - Tamosiunas, Abdonas - Bobák, Martin - Pikhart, Hynek
PY  - 2022
TI  - All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - Nature Publishing Group
SN  - 2045-2322
KW  - PULMONARY-FUNCTION
KW  - INCREASED RISK
KW  - FEV1
KW  - SPIROMETRY
KW  - PREDICTOR
KW  - INDIVIDUALS
KW  - ASSOCIATION
KW  - OUTCOMES
KW  - VALUES
UR  - https://www.nature.com/articles/s41598-022-17261-5
N2  - It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.
ER  -

SARYCHEVA, Tatyana Vladimirovna, Nadezda CAPKOVA, Andrzej PAJAK, Sofia MALYUTINA, Abdonas TAMOSIUNAS, Martin BOBÁK and Hynek PIKHART. All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts. \textit{Scientific Reports}. London: Nature Publishing Group, 2022, vol.~12, No~1, p.~1-9. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-17261-5.