All-cause and cardiovascular mortality in relation to lung
function in the full range of distribution across four Eastern
European cohorts

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All-cause and cardiovascular mortality in relation to lung function in the full range of ...

Přehled o publikaci

J 2022

All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Abdonas TAMOSIUNAS et. al.

Basic information

Original name

All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts

Authors

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Abdonas TAMOSIUNAS; Martin BOBÁK and Hynek PIKHART

Edition

Scientific Reports, London, Nature Publishing Group, 2022, 2045-2322

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Germany

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1038/s41598-022-17261-5

UT WoS

000833071900069

EID Scopus

2-s2.0-85135156680

Keywords in English

PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES

Links

EF17_043/0009632, research and development project. LX22NPO5104, research and development project. 857487, interní kód Repo. 857560, interní kód Repo.

Changed: 23/9/2022 03:39, RNDr. Daniel Jakubík

Abstract

V originále

It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.

Files attached

https://is.muni.cz/publication/2218237/2218237.pdf

Cite

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Abdonas TAMOSIUNAS; Martin BOBÁK and Hynek PIKHART. All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts. Scientific Reports. London: Nature Publishing Group, 2022, vol. 12, No 1, p. 1-9. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-17261-5.

@article{51848,
   author = {Sarycheva, Tatyana Vladimirovna and Capkova, Nadezda and Pajak, Andrzej and Malyutina, Sofia and Tamosiunas, Abdonas and Bobák, Martin and Pikhart, Hynek},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-17261-5},
   keywords = {PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts},
   url = {https://www.nature.com/articles/s41598-022-17261-5},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 51848
AU  - Sarycheva, Tatyana Vladimirovna - Capkova, Nadezda - Pajak, Andrzej - Malyutina, Sofia - Tamosiunas, Abdonas - Bobák, Martin - Pikhart, Hynek
PY  - 2022
TI  - All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-9
EP  - 1-9
PB  - Nature Publishing Group
SN  - 2045-2322
KW  - PULMONARY-FUNCTION
KW  - INCREASED RISK
KW  - FEV1
KW  - SPIROMETRY
KW  - PREDICTOR
KW  - INDIVIDUALS
KW  - ASSOCIATION
KW  - OUTCOMES
KW  - VALUES
UR  - https://www.nature.com/articles/s41598-022-17261-5
N2  - It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.
ER  -

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Abdonas TAMOSIUNAS; Martin BOBÁK and Hynek PIKHART. All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts. \textit{Scientific Reports}. London: Nature Publishing Group, 2022, vol.~12, No~1, p.~1-9. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-17261-5.