Authors
STUCHLÍK FIŠEROVÁ, Petra (203 Czech Republic, belonging to the institution), Lisa Emily MELYMUK (124 Canada, belonging to the institution), Klára KOMPRDOVÁ (203 Czech Republic, belonging to the institution), Elena DOMINGUEZ ROMERO (724 Spain, belonging to the institution), Martin SCHERINGER (756 Switzerland, belonging to the institution), Jiří KOHOUTEK (203 Czech Republic, belonging to the institution), Petra PŘIBYLOVÁ (203 Czech Republic, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Pavel PILER (203 Czech Republic, belonging to the institution), Holger M. KOCH, Martin ZVONAŘ (203 Czech Republic, belonging to the institution), Marta ESTEBAN-LOPEZ, Argelia CASTANO and Jana KLÁNOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Environmental Research, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, 0013-9351
Links
EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. 733032, interní kód Repo. 857560, interní kód Repo. RECETOX RI, large research infrastructures.
V originále
gt;99% of study participants. The highest median concentrations were found for metabolites of low-molecular-weight (LMW) phthalates: mono-n-butyl phthalate (MnBP), monoisobutyl phthalate (MiBP) and MEP (60.7; 52.6 and 17.6 mu g/L in young adults). 1,2-cyclohexanedicarboxylic acid diisononyl ester (DINCH) metabolites were present in 68.2% of the samples with a median of 1.24 mu g/L for both cohorts. Concentrations of MnBP and MiBP were similar to other European populations, but 5-6 times higher than in populations in North America. We also observed large variability in phthalate exposures within the study population, with 2-3 orders of magnitude differences in urinary metabolites between high and low exposed individuals. The concentrations varied with season, gender, age, and lifestyle factors. A relationship was found between high levels of MEP and high overall use of personal care products (PCPs). Cluster analysis suggested that phthalate exposures depend on season and multiple lifestyle factors, like time spent indoors and use of PCPs, which combine to lead to the observed widespread presence of phthalate metabolites in both study populations. Participants who spent more time indoors, particularly noticeably during colder months, had higher levels of high-molecular weight phthalate metabolites, whereas participants with higher PCP use, particularly women, tended to have higher concentration of LMW phthalate metabolites.