Přehled o publikaci
2021
ADAR RNA Modifications, the Epitranscriptome and Innate Immunity
QUIN, Jaclyn Elizabeth; Jiří SEDMÍK; Dragana VUKIĆ; Anzer KHAN; Liam KEEGAN et al.Basic information
Original name
ADAR RNA Modifications, the Epitranscriptome and Innate Immunity
Authors
QUIN, Jaclyn Elizabeth; Jiří SEDMÍK; Dragana VUKIĆ; Anzer KHAN; Liam KEEGAN and Mary Anne O'CONNELL
Edition
Trends in Biochemical Sciences, Cambridge (MA), Cell Press, 2021, 0968-0004
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
is not subject to a state or trade secret
References:
Marked to be transferred to RIV
Yes
RIV identification code
RIV/00216224:14740/21:00118989
Organization
Středoevropský technologický institut – Repository – Repository
UT WoS
EID Scopus
Keywords in English
RNA editing; double-stranded RNA (dsRNA); pattern recognition receptors (PRRs); interferon; antiviral responses; autoinflammatory disease
Links
GA19-16963S, research and development project. GA20-11101S, research and development project. GX21-27329X, research and development project. LTC18052, research and development project. 867470, interní kód Repo.
Changed: 6/5/2022 03:46, RNDr. Daniel Jakubík
Abstract
In the original language
Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations giving reduced levels of one base modification, adenosine-to-inosine deamination, cause a viral infection mimic syndrome, a congenital encephalitis with aberrant interferon induction. These Aicardi-Goutieres syndrome 6 mutations affect adenosine deaminase acting on RNA 1 (ADAR1), which generates inosines in endogenous double-stranded (ds)RNA. The inosine base alters dsRNA structure to prevent aberrant activation of antiviral cytosolic helicase RIG-I-like receptors. We review how effects of inosines, ADARs, and other modi-fied bases have been shown to be important in innate immunity and cancer.
