Přehled o publikaci
2022
Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes
HRUŠKA, Pavel; Jan KUČERA; Matej PEKAŘ; Pavol HOLÉCZY; Miloslav MAZUR et. al.Basic information
Original name
Proteomic Signatures of Human Visceral and Subcutaneous Adipocytes
Authors
HRUŠKA, Pavel; Jan KUČERA; Matej PEKAŘ; Pavol HOLÉCZY; Miloslav MAZUR; Marek BUZGA; Daniela KURUCZOVÁ; Peter LENÁRT; Jana FIALOVÁ KUČEROVÁ; David POTĚŠIL; Zbyněk ZDRÁHAL and Julie DOBROVOLNÁ
Edition
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2022, 0021-972X
Other information
Language
English
Type of outcome
Article in a journal
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
is not subject to a state or trade secret
References:
RIV identification code
RIV/00216224:14310/22:00125133
Organization
Přírodovědecká fakulta – Repository – Repository
UT WoS
000756897900013
EID Scopus
2-s2.0-85124850550
Keywords in English
adipose tissue; visceral adipose tissue; subcutaneous adipose tissue; obesity; adipocytes; metabolism
Links
EF15_003/0000469, research and development project. EF17_043/0009632, research and development project. LM2018140, research and development project. MUNI/A/1246/2020, interní kód Repo. MUNI/A/1307/2019, interní kód Repo. MUNI/A/1615/2020, interní kód Repo. MUNI/A/1698/2020, interní kód Repo. 857560, interní kód Repo. RECETOX RI, large research infrastructures. CIISB II, large research infrastructures.
Changed: 12/6/2025 00:49, RNDr. Daniel Jakubík
Abstract
In the original language
lt; 0.05), of which 576 proteins were upregulated in SA and 564 in VA samples. We provide a global protein profile of abdominal SA and omental VA, present the most differentially expressed pathways and processes distinguishing SA from VA, and correlate them with clinical and body composition data. We show that SA are significantly more active in processes linked to vesicular transport and secretion, and to increased lipid metabolism activity. Conversely, the expression of proteins involved in the mitochondria! energy metabolism and translational or biosynthetic activity is higher in VA. Conclusion: Our analysis represents a valuable resource of protein expression profiles in abdominal SA and omental VA, highlighting key differences in their role in obesity.
