Endocrine disrupting potential of replacement flame
retardants-Review of current knowledge for nuclear receptors
associated with reproductive outcomes

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Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for ...

Přehled o publikaci

J 2021

Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes

BAJARD ÉP.ESNER, Lola Murielle, Chander Kant NEGI, Vicente MUSTIELES, Lisa Emily MELYMUK, Stephane JOMINI et. al.

Basic information

Original name

Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes

Authors

BAJARD ÉP.ESNER, Lola Murielle (250 France, belonging to the institution), Chander Kant NEGI (356 India, belonging to the institution), Vicente MUSTIELES (724 Spain), Lisa Emily MELYMUK (124 Canada, belonging to the institution), Stephane JOMINI (250 France), Johanna BARTHELEMY-BERNERON (250 France), Mariana F. FERNANDEZ (724 Spain) and Luděk BLÁHA (203 Czech Republic, guarantor, belonging to the institution)

Edition

Environment International, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0160-4120

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14310/21:00122094

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.1016/j.envint.2021.106550

UT WoS

000652671200002

EID Scopus

2-s2.0-85103932738

Keywords in English

Endocrine disruption; Nuclear receptors; Steroid hormones; Flame retardants; Emerging contaminants; ToxCast

Links

EF17_043/0009632, research and development project. 733032, interní kód Repo. 857560, interní kód Repo. 859891, interní kód Repo. RECETOX RI, large research infrastructures.

Changed: 6/6/2025 00:49, RNDr. Daniel Jakubík

Abstract

V originále

Background and aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Methods: A systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement FRs towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables. Findings were complemented with information from structure-based in silico model predictions and in vivo information when relevant. Results: For the majority of the 52 replacement FRs, experimental in vitro data on activities towards these five NRs were either incomplete (15 FRs) or not found (24 FRs). Within the replacement FRs for which effect data were found, some appeared as candidate EDCs, such as triphenyl phosphate (TPhP) and tris(1,3-dichloropropyl) phosphate (TDCIPP). The search also revealed shared ED profiles. For example, anti-androgenic activity was reported for 19 FRs and predicted for another 21 FRs. Discussion: This comprehensive review points to critical gaps in knowledge on ED potential for many replacement FRs, including chemicals to which the general population is likely exposed. Although this review does not cover all possible characteristics of ED, it allowed the identification of potential EDCs associated with reproductive outcomes, calling for deeper evaluation and possibly future regulation of these chemicals. By identifying shared ED profiles, this work also raises concerns for mixture effects since the population is co-exposed to several FRs and other chemicals.

Files attached

https://is.muni.cz/publication/1786147/1786147.pdf

Cite

BAJARD ÉP.ESNER, Lola Murielle, Chander Kant NEGI, Vicente MUSTIELES, Lisa Emily MELYMUK, Stephane JOMINI, Johanna BARTHELEMY-BERNERON, Mariana F. FERNANDEZ and Luděk BLÁHA. Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes. Environment International. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol. 153, August 2021, p. 1-12. ISSN 0160-4120. Available from: https://dx.doi.org/10.1016/j.envint.2021.106550.

@article{48233,
   author = {Bajard ép.Esner, Lola Murielle and Negi, Chander Kant and Mustieles, Vicente and Melymuk, Lisa Emily and Jomini, Stephane and BarthelemyandBerneron, Johanna and Fernandez, Mariana F. and Bláha, Luděk},
   article_location = {OXFORD},
   article_number = {August 2021},
   doi = {http://dx.doi.org/10.1016/j.envint.2021.106550},
   keywords = {Endocrine disruption; Nuclear receptors; Steroid hormones; Flame retardants; Emerging contaminants; ToxCast},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes},
   url = {https://www.sciencedirect.com/science/article/pii/S0160412021001756?via%3Dihub},
   volume = {153},
   year = {2021}
}

TY  - JOUR
ID  - 48233
AU  - Bajard ép.Esner, Lola Murielle - Negi, Chander Kant - Mustieles, Vicente - Melymuk, Lisa Emily - Jomini, Stephane - Barthelemy-Berneron, Johanna - Fernandez, Mariana F. - Bláha, Luděk
PY  - 2021
TI  - Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes
JF  - Environment International
VL  - 153
IS  - August 2021
SP  - 1-12
EP  - 1-12
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 0160-4120
KW  - Endocrine disruption
KW  - Nuclear receptors
KW  - Steroid hormones
KW  - Flame retardants
KW  - Emerging contaminants
KW  - ToxCast
UR  - https://www.sciencedirect.com/science/article/pii/S0160412021001756?via%3Dihub
N2  - Background and aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Methods: A systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement FRs towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables. Findings were complemented with information from structure-based in silico model predictions and in vivo information when relevant. Results: For the majority of the 52 replacement FRs, experimental in vitro data on activities towards these five NRs were either incomplete (15 FRs) or not found (24 FRs). Within the replacement FRs for which effect data were found, some appeared as candidate EDCs, such as triphenyl phosphate (TPhP) and tris(1,3-dichloropropyl) phosphate (TDCIPP). The search also revealed shared ED profiles. For example, anti-androgenic activity was reported for 19 FRs and predicted for another 21 FRs. Discussion: This comprehensive review points to critical gaps in knowledge on ED potential for many replacement FRs, including chemicals to which the general population is likely exposed. Although this review does not cover all possible characteristics of ED, it allowed the identification of potential EDCs associated with reproductive outcomes, calling for deeper evaluation and possibly future regulation of these chemicals. By identifying shared ED profiles, this work also raises concerns for mixture effects since the population is co-exposed to several FRs and other chemicals.
ER  -

BAJARD ÉP.ESNER, Lola Murielle, Chander Kant NEGI, Vicente MUSTIELES, Lisa Emily MELYMUK, Stephane JOMINI, Johanna BARTHELEMY-BERNERON, Mariana F. FERNANDEZ and Luděk BLÁHA. Endocrine disrupting potential of replacement flame retardants-Review of current knowledge for nuclear receptors associated with reproductive outcomes. \textit{Environment International}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol.~153, August 2021, p.~1-12. ISSN~0160-4120. Available from: https://dx.doi.org/10.1016/j.envint.2021.106550.