J
2020
Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells
ČTVERÁČKOVÁ, Lucie; Daniel JANČULA; Jan RAŠKA; Pavel BABICA; Iva SOVADINOVÁ et. al.
Basic information
Original name
Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells
Authors
ČTVERÁČKOVÁ, Lucie; Daniel JANČULA; Jan RAŠKA; Pavel BABICA and Iva SOVADINOVÁ
Edition
International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2020, 1422-0067
Other information
Type of outcome
Article in a journal
Country of publisher
Switzerland
Confidentiality degree
is not subject to a state or trade secret
RIV identification code
RIV/00216224:14310/20:00114568
Organization
Přírodovědecká fakulta – Repository – Repository
EID Scopus
2-s2.0-85089924980
Keywords in English
gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells
Links
EF17_043/0009632, research and development project. GJ16-10775Y, research and development project. 857560, interní kód Repo. RECETOX RI, large research infrastructures.
In the original language
gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.
Displayed: 13/12/2025 13:53