Structure-Dependent Effects of Phthalates on Intercellular and
Intracellular Communication in Liver Oval Cells

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Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver ...

Přehled o publikaci

J 2020

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells

ČTVERÁČKOVÁ, Lucie, Daniel JANČULA, Jan RAŠKA, Pavel BABICA, Iva SOVADINOVÁ et. al.

Basic information

Original name

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells

Authors

ČTVERÁČKOVÁ, Lucie (203 Czech Republic, belonging to the institution), Daniel JANČULA (203 Czech Republic), Jan RAŠKA (203 Czech Republic, belonging to the institution), Pavel BABICA (203 Czech Republic, belonging to the institution) and Iva SOVADINOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2020, 1422-0067

Other information

Language

English

Type of outcome

Article in a journal

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

RIV identification code

RIV/00216224:14310/20:00114568

Organization

Přírodovědecká fakulta – Repository – Repository

DOI

http://dx.doi.org/10.3390/ijms21176069

UT WoS

000569736100001

EID Scopus

2-s2.0-85089924980

Keywords in English

gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells

Links

EF17_043/0009632, research and development project. GJ16-10775Y, research and development project. 857560, interní kód Repo. RECETOX RI, large research infrastructures.

Changed: 3/6/2025 00:50, RNDr. Daniel Jakubík

Abstract

V originále

gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.

Files attached

https://is.muni.cz/publication/1708576/1708576.pdf

Cite

ČTVERÁČKOVÁ, Lucie, Daniel JANČULA, Jan RAŠKA, Pavel BABICA and Iva SOVADINOVÁ. Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2020, vol. 21, No 17, p. 1-21. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms21176069.

@article{45506,
   author = {Čtveráčková, Lucie and Jančula, Daniel and Raška, Jan and Babica, Pavel and Sovadinová, Iva},
   article_location = {Basel},
   article_number = {17},
   doi = {http://dx.doi.org/10.3390/ijms21176069},
   keywords = {gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells},
   url = {https://www.mdpi.com/1422-0067/21/17/6069},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 45506
AU  - Čtveráčková, Lucie - Jančula, Daniel - Raška, Jan - Babica, Pavel - Sovadinová, Iva
PY  - 2020
TI  - Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells
JF  - International Journal of Molecular Sciences
VL  - 21
IS  - 17
SP  - 1-21
EP  - 1-21
PB  - Multidisciplinary Digital Publishing Institute
SN  - 1422-0067
KW  - gap junctional intercellular communication
KW  - gap junctions
KW  - hepatotoxicity
KW  - MAP-kinases Erk1
KW  - 2 activation
KW  - non-genomic mechanism
KW  - oval cells
KW  - phthalates
KW  - progenitor cells
UR  - https://www.mdpi.com/1422-0067/21/17/6069
N2  - gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.
ER  -

ČTVERÁČKOVÁ, Lucie, Daniel JANČULA, Jan RAŠKA, Pavel BABICA and Iva SOVADINOVÁ. Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, vol.~21, No~17, p.~1-21. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms21176069.