Structure-Dependent Effects of Phthalates on Intercellular and
Intracellular Communication in Liver Oval Cells

ENPřihlásit se Přihlásit se (EduID)

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver ...

Přehled o publikaci

J 2020

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells

ČTVERÁČKOVÁ, Lucie, Daniel JANČULA, Jan RAŠKA, Pavel BABICA, Iva SOVADINOVÁ et. al.

Základní údaje

Originální název

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells

Autoři

ČTVERÁČKOVÁ, Lucie (203 Česká republika, domácí), Daniel JANČULA (203 Česká republika), Jan RAŠKA (203 Česká republika, domácí), Pavel BABICA (203 Česká republika, domácí) a Iva SOVADINOVÁ (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2020, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14310/20:00114568

Organizace

Přírodovědecká fakulta – Masarykova univerzita – Repozitář

DOI

http://dx.doi.org/10.3390/ijms21176069

UT WoS

000569736100001

EID Scopus

2-s2.0-85089924980

Klíčová slova anglicky

gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells

Návaznosti

EF17_043/0009632, projekt VaV. GJ16-10775Y, projekt VaV. 857560, interní kód Repo. RECETOX RI, velká výzkumná infrastruktura.

Změněno: 3. 6. 2025 00:50, RNDr. Daniel Jakubík

Anotace

V originále

gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.

Přiložené soubory

https://is.muni.cz/publication/1708576/1708576.pdf

Citovat

ČTVERÁČKOVÁ, Lucie, Daniel JANČULA, Jan RAŠKA, Pavel BABICA a Iva SOVADINOVÁ. Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč. 21, č. 17, s. 1-21. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21176069.

@article{45506,
   author = {Čtveráčková, Lucie and Jančula, Daniel and Raška, Jan and Babica, Pavel and Sovadinová, Iva},
   article_location = {Basel},
   article_number = {17},
   doi = {http://dx.doi.org/10.3390/ijms21176069},
   keywords = {gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells},
   url = {https://www.mdpi.com/1422-0067/21/17/6069},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 45506
AU  - Čtveráčková, Lucie - Jančula, Daniel - Raška, Jan - Babica, Pavel - Sovadinová, Iva
PY  - 2020
TI  - Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells
JF  - International Journal of Molecular Sciences
VL  - 21
IS  - 17
SP  - 1-21
EP  - 1-21
PB  - Multidisciplinary Digital Publishing Institute
SN  - 1422-0067
KW  - gap junctional intercellular communication
KW  - gap junctions
KW  - hepatotoxicity
KW  - MAP-kinases Erk1
KW  - 2 activation
KW  - non-genomic mechanism
KW  - oval cells
KW  - phthalates
KW  - progenitor cells
UR  - https://www.mdpi.com/1422-0067/21/17/6069
N2  - gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.
ER  -

ČTVERÁČKOVÁ, Lucie, Daniel JANČULA, Jan RAŠKA, Pavel BABICA a Iva SOVADINOVÁ. Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč.~21, č.~17, s.~1-21. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21176069.