Structure-Dependent Effects of Phthalates on Intercellular and
Intracellular Communication in Liver Oval Cells

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Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver ...

Přehled o publikaci

J 2020

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells

ČTVERÁČKOVÁ, Lucie; Daniel JANČULA; Jan RAŠKA; Pavel BABICA; Iva SOVADINOVÁ et. al.

Základní údaje

Originální název

Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells

Autoři

ČTVERÁČKOVÁ, Lucie (203 Česká republika, domácí); Daniel JANČULA (203 Česká republika); Jan RAŠKA (203 Česká republika, domácí); Pavel BABICA (203 Česká republika, domácí) a Iva SOVADINOVÁ (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2020, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14310/20:00114568

Organizace

Přírodovědecká fakulta – Masarykova univerzita – Repozitář

DOI

http://dx.doi.org/10.3390/ijms21176069

UT WoS

000569736100001

EID Scopus

2-s2.0-85089924980

Klíčová slova anglicky

gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells

Návaznosti

EF17_043/0009632, projekt VaV. GJ16-10775Y, projekt VaV. 857560, interní kód Repo. RECETOX RI, velká výzkumná infrastruktura.

Změněno: 3. 6. 2025 00:50, RNDr. Daniel Jakubík

Anotace

V originále

gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.

Přiložené soubory

https://is.muni.cz/publication/1708576/1708576.pdf

Citovat

ČTVERÁČKOVÁ, Lucie; Daniel JANČULA; Jan RAŠKA; Pavel BABICA a Iva SOVADINOVÁ. Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč. 21, č. 17, s. 1-21. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21176069.

@article{45506,
   author = {Čtveráčková, Lucie and Jančula, Daniel and Raška, Jan and Babica, Pavel and Sovadinová, Iva},
   article_location = {Basel},
   article_number = {17},
   doi = {http://dx.doi.org/10.3390/ijms21176069},
   keywords = {gap junctional intercellular communication; gap junctions; hepatotoxicity; MAP-kinases Erk1; 2 activation; non-genomic mechanism; oval cells; phthalates; progenitor cells},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells},
   url = {https://www.mdpi.com/1422-0067/21/17/6069},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 45506
AU  - Čtveráčková, Lucie - Jančula, Daniel - Raška, Jan - Babica, Pavel - Sovadinová, Iva
PY  - 2020
TI  - Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells
JF  - International Journal of Molecular Sciences
VL  - 21
IS  - 17
SP  - 1-21
EP  - 1-21
PB  - Multidisciplinary Digital Publishing Institute
SN  - 1422-0067
KW  - gap junctional intercellular communication
KW  - gap junctions
KW  - hepatotoxicity
KW  - MAP-kinases Erk1
KW  - 2 activation
KW  - non-genomic mechanism
KW  - oval cells
KW  - phthalates
KW  - progenitor cells
UR  - https://www.mdpi.com/1422-0067/21/17/6069
N2  - gt;12 h), suggesting that GJIC dysregulation occurs via genomic mechanisms, or (bio)transformation. Overall, medium-chain phthalates rapidly affected the key tissue homeostatic mechanisms in the liver oval cell population via non-genomic pathways, which might contribute to the development of chronic liver toxicity and diseases.
ER  -

ČTVERÁČKOVÁ, Lucie; Daniel JANČULA; Jan RAŠKA; Pavel BABICA a Iva SOVADINOVÁ. Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč.~21, č.~17, s.~1-21. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21176069.