ŠVAJDOVÁ, Michaela, Marián SIČÁK, Pavol DUBINSKÝ, Marek SLÁVIK, Pavel ŠLAMPA a Tomáš KAZDA. Recurrent Nasopharyngeal Cancer: Critical Review of Local Treatment Options Including Recommendations during the COVID-19 Pandemic. Cancers. BASEL: MDPI, roč. 12, č. 12, s. 1-19. ISSN 2072-6694. doi:10.3390/cancers12123510. 2020.
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Základní údaje
Originální název Recurrent Nasopharyngeal Cancer: Critical Review of Local Treatment Options Including Recommendations during the COVID-19 Pandemic
Autoři ŠVAJDOVÁ, Michaela (703 Slovensko, garant, domácí), Marián SIČÁK (703 Slovensko), Pavol DUBINSKÝ (703 Slovensko), Marek SLÁVIK (703 Slovensko, domácí), Pavel ŠLAMPA (203 Česká republika) a Tomáš KAZDA (203 Česká republika).
Vydání Cancers, BASEL, MDPI, 2020, 2072-6694.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Kód RIV RIV/00216224:14110/20:00117103
Organizace Lékařská fakulta – Masarykova univerzita – Repozitář
Doi http://dx.doi.org/10.3390/cancers12123510
UT WoS 000601666500001
Klíčová slova anglicky nasopharyngeal cancer; recurrence; salvage surgery; re-irradiation; toxicity
Změnil Změnil: RNDr. Daniel Jakubík, učo 139797. Změněno: 11. 10. 2021 02:16.
Anotace
Options for the curative treatment of locally recurrent nasopharyngeal carcinoma include surgery or re-irradiation. Both approaches have been scientifically explored, yet there is no consensus on the indication or definitive preference of the above two salvage treatments. The aim of this review is to summarize the current evidence on the local treatment of recurrent nasopharyngeal carcinoma. The feasibility, safety, and efficacy of salvage surgery and radical re-irradiation are discussed. Recommendations on treatment modifications during the coronavirus disease 2019 pandemic are included as well. Recurrent nasopharyngeal carcinoma represents an extremely challenging therapeutic situation. Given the vulnerability of the already pretreated neurological structures surrounding the nasopharynx, any potential salvage retreatment option bears a significant risk of severe complications that result in high treatment-related morbidity, quality of life deterioration, and even mortality. Yet, with careful patient selection, long-term survival may be achieved after local retreatment in a subgroup of patients with local or regional relapse of nasopharyngeal cancer. Early detection of the recurrence represents the key to therapeutic success, and in the case of early stage disease, several curative treatment options can be offered to the patient, albeit with minimal support in prospective clinical data. In this article, an up-to-date review of published evidence on modern surgical and radiation therapy treatment options is summarized, including currently recommended treatment modifications of both therapeutic approaches during the coronavirus disease 2019 pandemic.
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