HEGER, Zbynek, Hana POLANSKÁ, Miguel Angel Merlos RODRIGO, Roman GURÁŇ, Pavel KULICH, Pavel KOPEL, Michal MASAŘÍK, Tomas ECKSCHLAGER, Marie STIBOROVA, Rene KIZEK and Vojtech ADAM. Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes. Scientific Reports. London: Nature Publishing Group, vol. 6, No 33379, p. 1-11. ISSN 2045-2322. 2016.
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Basic information
Original name Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes
Authors HEGER, Zbynek (203 Czech Republic), Hana POLANSKÁ (203 Czech Republic, belonging to the institution), Miguel Angel Merlos RODRIGO (203 Czech Republic), Roman GURÁŇ (203 Czech Republic), Pavel KULICH (203 Czech Republic), Pavel KOPEL (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution), Tomas ECKSCHLAGER (203 Czech Republic), Marie STIBOROVA (203 Czech Republic), Rene KIZEK (203 Czech Republic) and Vojtech ADAM (203 Czech Republic).
Edition Scientific Reports, London, Nature Publishing Group, 2016, 2045-2322.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Oncology and haematology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14110/16:00090895
Organization Lékařská fakulta – Repository – Repository
UT WoS 000383485100001
Keywords in English CANCER PROGRESSION; CELL-LINE; IN-VITRO; METALLOTHIONEIN; EXPRESSION; THERAPY; PROTEIN; URINE; NANOPARTICLES; TRAFFICKING
Links LQ1601, research and development project.
Changed by Changed by: RNDr. Daniel Jakubík, učo 139797. Changed: 3/9/2020 05:47.
Abstract
Herein, we describe the preparation of liposomes with folate-targeting properties for the encapsulation of anti-sarcosine antibodies (antisarAbs@LIP) and sarcosine (sar@LIP). The competitive inhibitory effects of exogenously added folic acid supported the role of folate targeting in liposome internalization. We examined the effects of repeated administration on mice PC-3 xenografts. Sar@LIP treatment significantly increased tumor volume and weight compared to controls treated with empty liposomes. Moreover, antisarAbs@LIP administration exhibited a mild antitumor effect. We also identified differences in gene expression patterns post-treatment. Furthermore, Sar@LIP treatment resulted in decreased amounts of tumor zinc ions and total metallothioneins. Examination of the spatial distribution across the tumor sections revealed a sarcosine-related decline of the MT1X isoform within the marginal regions but an elevation after antisarAbs@LIP administration. Our exploratory results demonstrate the importance of sarcosine as an oncometabolite in PCa. Moreover, we have shown that sarcosine can be a potential target for anticancer strategies in management of PCa.
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